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      Differential Regulation of the Two Forms of Gonadotropin-Releasing Hormone (mGnRH and cGnRH-II) by Sex Steroids in the European Female Silver Eel (Anguilla anguilla)

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          Abstract

          The effect of steroids on the two gonadotropin-releasing hormone (GnRH) forms present in the eel (mammalian GnRH, mGnRH and chicken GnRH-II, cGnRH-II), as well as on gonadotropin (GTH), was studied using specific radioimmunoassays. Female silver eels received chronic treatments with various steroids (estradiol, testosterone, androstenedione, 5α-androstane-3β,17β-diol). Estradiol or the combination of estradiol and androgens induced increases in brain and pituitary mGnRH levels and pituitary GTH level, whereas androgens given alone had no significant effect. In contrast, androgens or their combination with estradiol reduced brain cGnRH-II levels (this form remaining undetectable in the pituitary), estradiol given alone having no significant effect. This work demonstrates that the two forms of GnRH undergo a differential regulation by steroids, with a positive estrogen-dependent feedback on mGnRH (as well as on GTH) and a negative androgen-dependent feedback on cGnRH-II. These data are in agreement with previous results obtained in experimentally matured female eels (induced by a gonadotropic treatment which stimulates the production of both estrogens and androgens) showing increases in mGnRH and GTH levels, as well as a decrease in cGnRH-II [1]. The positive feedback of steroids on the mGnRH-GTH axis adds credence to the hypothesis according to which mGnRH would be the main form involved in the control of the gonadotropic function. This positive feedback would play an important role, amplifying pubertal stimulation of the gonadotropic axis, in this fish species.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1995
          1995
          09 April 2008
          : 61
          : 5
          : 525-535
          Affiliations
          aLaboratoire de Physiologie Générate et Comparée, Muséum National d’Histoire Naturelle, URA 90 CNRS, Paris, France; bMedical Research Council Regulatory Peptides Research Unit, Department of Chemical Pathology, University of Cape Town Medical School, and Groote Schuur Hospital, Cape Town, South Africa
          Article
          126876 Neuroendocrinology 1995;61:525–535
          10.1159/000126876
          7617130
          © 1995 S. Karger AG, Basel

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          Page count
          Pages: 11
          Categories
          Organization and Regulation of Hypothalamic Neurons

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