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      Influence of bFGF as a Potent Growth Stimulator and TGF-β as a Growth Regulator on Scleral Chondrocytes and Scleral Fibroblasts in vitro

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          Abstract

          We investigated the proliferation of scleral cells in response to several growth factors in vitro to elucidate the mechanism of scleral growth in visual deprivation myopia. Scleral chondrocytes and scleral fibroblasts were cultured separately in 24-well culture dishes. The number of plated cells was counted after the addition of basic fibroblast growth factor (bFGF), transforming growth factor α (TGF-α), TGF-β, insulin-like growth factor I (IGF-I), IGF-II, platelet-derived growth factor AA (PDGF-AA), PDGF-AB and PDGF-BB. All the growth factors studied, except for PDGF-AA, stimulated the proliferation of both scleral chondrocytes and scleral fibroblasts. bFGF showed the highest effect. TGF-β caused morphologic changes in both scleral chondrocytes and scleral fibroblasts. Various growth factors stimulated the proliferation of scleral chondrocytes and scleral fibroblasts in a similar manner. bFGF was a potent growth stimulator and TGF-β was suggested to be a growth regulator on scleral chondrocytes and scleral fibroblasts.

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          Author and article information

          Journal
          ORE
          Ophthalmic Res
          10.1159/issn.0030-3747
          Ophthalmic Research
          S. Karger AG
          0030-3747
          1423-0259
          1995
          1995
          11 December 2009
          : 27
          : 3
          : 144-152
          Affiliations
          aDepartment of Ophthalmology, Tokyo Medical and Dental University School of Medicine, and bDepartment of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
          Article
          267651 Ophthalmic Res 1995;27:144–152
          10.1159/000267651
          8538991
          © 1995 S. Karger AG, Basel

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          Page count
          Pages: 9
          Categories
          Original Paper

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