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      Influence of bFGF as a Potent Growth Stimulator and TGF-β as a Growth Regulator on Scleral Chondrocytes and Scleral Fibroblasts in vitro

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          Abstract

          We investigated the proliferation of scleral cells in response to several growth factors in vitro to elucidate the mechanism of scleral growth in visual deprivation myopia. Scleral chondrocytes and scleral fibroblasts were cultured separately in 24-well culture dishes. The number of plated cells was counted after the addition of basic fibroblast growth factor (bFGF), transforming growth factor α (TGF-α), TGF-β, insulin-like growth factor I (IGF-I), IGF-II, platelet-derived growth factor AA (PDGF-AA), PDGF-AB and PDGF-BB. All the growth factors studied, except for PDGF-AA, stimulated the proliferation of both scleral chondrocytes and scleral fibroblasts. bFGF showed the highest effect. TGF-β caused morphologic changes in both scleral chondrocytes and scleral fibroblasts. Various growth factors stimulated the proliferation of scleral chondrocytes and scleral fibroblasts in a similar manner. bFGF was a potent growth stimulator and TGF-β was suggested to be a growth regulator on scleral chondrocytes and scleral fibroblasts.

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          Author and article information

          Journal
          ORE
          Ophthalmic Res
          10.1159/issn.0030-3747
          Ophthalmic Research
          S. Karger AG
          0030-3747
          1423-0259
          1995
          1995
          11 December 2009
          : 27
          : 3
          : 144-152
          Affiliations
          aDepartment of Ophthalmology, Tokyo Medical and Dental University School of Medicine, and bDepartment of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
          Article
          267651 Ophthalmic Res 1995;27:144–152
          10.1159/000267651
          8538991
          7c9ca532-9b4f-4093-b025-8a11628a3780
          © 1995 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          : 25 October 1994
          : 03 January 1995
          Page count
          Pages: 9
          Categories
          Original Paper

          Vision sciences,Ophthalmology & Optometry,Pathology
          Chondrocyte,Sclera,Fibroblast,Fibroblast growth factor, basic,Transforming growth factor β

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