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      Influence of bFGF as a Potent Growth Stimulator and TGF-β as a Growth Regulator on Scleral Chondrocytes and Scleral Fibroblasts in vitro

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          We investigated the proliferation of scleral cells in response to several growth factors in vitro to elucidate the mechanism of scleral growth in visual deprivation myopia. Scleral chondrocytes and scleral fibroblasts were cultured separately in 24-well culture dishes. The number of plated cells was counted after the addition of basic fibroblast growth factor (bFGF), transforming growth factor α (TGF-α), TGF-β, insulin-like growth factor I (IGF-I), IGF-II, platelet-derived growth factor AA (PDGF-AA), PDGF-AB and PDGF-BB. All the growth factors studied, except for PDGF-AA, stimulated the proliferation of both scleral chondrocytes and scleral fibroblasts. bFGF showed the highest effect. TGF-β caused morphologic changes in both scleral chondrocytes and scleral fibroblasts. Various growth factors stimulated the proliferation of scleral chondrocytes and scleral fibroblasts in a similar manner. bFGF was a potent growth stimulator and TGF-β was suggested to be a growth regulator on scleral chondrocytes and scleral fibroblasts.

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          Author and article information

          Ophthalmic Res
          Ophthalmic Research
          S. Karger AG
          11 December 2009
          : 27
          : 3
          : 144-152
          aDepartment of Ophthalmology, Tokyo Medical and Dental University School of Medicine, and bDepartment of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
          267651 Ophthalmic Res 1995;27:144–152
          © 1995 S. Karger AG, Basel

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          Pages: 9
          Original Paper


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