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      Presence of Anterior Communicating Artery Aneurysm Is Associated With Age, Bifurcation Angle, and Vessel Diameter

      1 , 1 , 1 , 1 , 1
      Stroke
      Ovid Technologies (Wolters Kluwer Health)

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          Most cited references18

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          The Physiological Principle of Minimum Work: I. The Vascular System and the Cost of Blood Volume.

          C. Murray (1926)
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            Review of cerebral aneurysm formation, growth, and rupture.

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              Computation of hemodynamics in the circle of Willis.

              Wall shear stress (WSS) and pressure are important factors in the development of cerebral aneurysms. We aimed to develop a computational fluid dynamics simulator for flow in the complete circle of Willis to study the impact of variations in vessel radii and bifurcation angles on WSS and pressure on vessel walls. Blood flow was modeled with Navier-Stokes equations as an incompressible newtonian fluid within rigid vessel walls. A model of the circle of Willis geometry was approximated as a network of tubes around cubic curves. Pulsatile inlet flow rates and constant outlet pressure were used as boundary conditions. The simulations confirmed that differences in vessel radii and asymmetric branch angles influence WSS magnitude and spatial distribution. High WSS occurred at locations where aneurysms are frequent and in anatomic variants known to be associated with an increased risk for aneurysm development. Computational fluid dynamics analysis can be applied to the complete circle of Willis and should be used to study the pathophysiology of this complex vascular structure, including risk factors for aneurysm development. Further development of the method should include simulations with flexible vessel walls.
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                Author and article information

                Journal
                Stroke
                Stroke
                Ovid Technologies (Wolters Kluwer Health)
                0039-2499
                1524-4628
                February 2018
                February 2018
                : 49
                : 2
                : 341-347
                Affiliations
                [1 ]From the Department of Interventional Therapy, Henan Provincial People’s Hospital, Zhengzhou, Henan Province, China (X.-J.Z., B.-L.G., W.-L.H., S.-S.W.); Department of Medical Research, Shijiazhuang First Hospital, Hebei Medical University, Hebei Province, China (X.-J.Z., B.-L.G., W.-L. H., S.-S. W.); and Henan Balance Medical Laboratory, Zhengzhou, Henan Province, China (D.-H.Z.).
                Article
                10.1161/STROKEAHA.117.019701
                29301972
                7cb0e548-2e55-473d-952a-d8ea1069972e
                © 2018
                History

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