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      Layer V cortical neurons require microglial support for survival during postnatal development.

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          Abstract

          Neurons require trophic support during neural circuit formation; however, how the cellular milieu contributes to neuronal survival remains unclear. We found that layer V cortical neurons require support from microglia for survival during postnatal development. Specifically, we found that microglia accumulated close to the subcerebral and callosal projection axons in the postnatal brain. Inactivation of microglia by minocycline treatment or transient ablation of microglia in CD11b-DTR transgenic mice led to increased apoptosis, specifically in layer V subcerebral and callosal projection neurons. CX3CR1 in microglia was required for the survival of layer V neurons. Microglia consistently promoted the survival of cortical neurons in vitro. In addition, we identified microglia-derived IGF1 as a trophic factor that maintained neuronal survival. Our results highlight a neuron-glia interaction that is indispensable for network formation during a specific period in the developing brain.

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          Author and article information

          Journal
          Nat Neurosci
          Nature neuroscience
          Springer Science and Business Media LLC
          1546-1726
          1097-6256
          May 2013
          : 16
          : 5
          Affiliations
          [1 ] Department of Molecular Neuroscience, Graduate School of Medicine, Osaka University, Osaka, Japan. ms-ueno@umin.ac.jp
          Article
          nn.3358
          10.1038/nn.3358
          23525041
          7cb1ea46-a2a3-457c-90a5-4da246848c96
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