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      Increased Level of HLA-DR-Expressing T Lymphocytes in Peripheral Blood from Patients with Idiopathic Dilated Cardiomyopathy

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      a , a , b
      Cardiology
      S. Karger AG
      Idiopathic dilated cardiomyopathy, Lymphocytes, HLA-DR antigen

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          Abstract

          Peripheral blood leukocytes from 14 patients with idiopathic dilated cardiomyopathy (IDC), 13 patients with ischemic congestive heart failure, and 12 controls were characterized using different antibodies. The proportions of B lymphocytes, T lymphocytes, and the different T lymphocyte subsets were estimated. No difference between the three groups could be found in the various T and B cells subpopulations. Using a two-color direct immunofluorescence technique, the occurrence of circulating T helper/inducer (Leu-3a) and T cytotoxic/suppressor cells (Leu-2a) expressing HLA-DR antigens was examined. Only IDC patients demonstrated increased levels of HLA-DR-positive T helper/inducer cells (2.8 ± 2.4%) and T cytotoxic/suppressor cells (2.8 ± 2.3%) as compared with patients with ischemic congestive heart failure (0.8 ± 0.7 and 1.0 ± 1.0%, respectively) and controls (0.6 ± 0.5 and 0.9 ± 0.6%, respectively). When individual IDC patients were studied, 4 out of 12 patients had an increased level of HLA-DR-expressing T helper/inducer cells, and 7 out of 12 patients had elevated HLA-DR-positive T cytotoxic/suppressor cells. The findings suggest that activation of the T lymphocytes may be of importance in the pathogenesis of IDC.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          0008-6312
          1421-9751
          1991
          1991
          12 November 2008
          : 78
          : 3
          : 161-167
          Affiliations
          Departments of aInternal Medicine and bClinical Chemistry, Central Hospital, Luleå/Boden, Sweden
          Article
          174781 Cardiology 1991;78:161–167
          10.1159/000174781
          1868494
          7cbdc14d-c24c-4561-8493-1142341305a4
          © 1991 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          : 13 July 1990
          : 19 October 1990
          Page count
          Pages: 7
          Categories
          General Cardiology

          General medicine,Neurology,Cardiovascular Medicine,Internal medicine,Nephrology
          Lymphocytes,Idiopathic dilated cardiomyopathy,HLA-DR antigen

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