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      Association of Achieving Lupus Low Disease Activity State Fifty Percent of the Time With Both Reduced Damage Accrual and Mortality in Patients With Systemic Lupus Erythematosus

      Author(s): 1 , 2 , 3 , 4
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      Journal: Arthritis Care & Research
      Publisher: Wiley

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          Abstract

          To assess the impact of achieving Lupus Low Disease Activity State ≥50% of the time (LLDAS-50) on damage accrual and mortality in an inception cohort of patients with systemic lupus erythematosus (SLE).

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          Damage and mortality in a group of British patients with systemic lupus erythematosus followed up for over 10 years.

          S Chambers, Kazi Rahman, Anisur Rahman … (2009)
          To study damage accrual and mortality in British patients with SLE under long-term follow-up for >10 years. We analysed the clinical records of 232 patients with SLE who had at least 10 years of consistent follow-up at University College London Hospital (UCLH). We noted their SLICC/ACR Damage Index (SDI) scores and category of damage at 1 year post-diagnosis of SLE and every 5 years thereafter. For patients who had died, we determined the year and cause of death. Ninety per cent of patients had no damage at 1 year post-diagnosis of SLE; however by year 10, 50% had accrued some damage. Damage accrual was mostly in the neuropsychiatric, renal and musculoskeletal categories. An increase in damage score was associated with a higher risk of death overall. Forty-four patients died during the period of follow-up. Sepsis, cancer and organ failure (cardiac, renal and liver) were the main causes of death in this group of patients. Damage accrual is associated with an increased risk of mortality. Infections remain an important cause of death in patients with SLE.
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            Lupus low disease activity state is associated with a decrease in damage progression in Caucasian patients with SLE, but overlaps with remission.

            Margherita Zen, Luca Iaccarino, Mariele Gatto … (2018)
            To evaluate the prevalence, duration and effect on damage accrual of the 'Lupus Low Disease Activity State' (LLDAS) in a monocentric cohort of patients with systemic lupus erythematosus (SLE).
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              Both prolonged remission and Lupus Low Disease Activity State are associated with reduced damage accrual in systemic lupus erythematosus.

              Alexandre E Voskuyl, Michel Tsang-A-Sjoe, Irene E. M. Bultink … (2017)
              To identify predictors of organ damage and specifically the relationship between prolonged disease remission or low disease activity and damage accrual in a longitudinal cohort of SLE patients.
              Article 0 comments Cited 51 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Title: Arthritis Care & Research
                Abbreviated Title: Arthritis Care Res
                Publisher: Wiley
                ISSN (Print): 2151-464X
                ISSN (Electronic): 2151-4658
                Publication date Created: February 27 2020
                Publication date Created: March 2020
                Publication date (Electronic): February 27 2020
                Publication date (Print): March 2020
                Volume: 72
                Issue: 3
                Pages: 447-451
                Affiliations
                [1 ]Sir Charles Gairdner Hospital Perth Australia
                [2 ]School of MedicineUniversity of Western Australia Crawley Australia
                [3 ]Arctic University Tromsø Norway
                [4 ]Sir Charles Gairdner Hospital, Perth, Australia and School of Medicine, University of Western Australia Crawley Australia
                Article
                DOI: 10.1002/acr.23867
                PubMed ID: 30821926
                SO-VID: 7cc139e3-8610-4284-b3cc-eebb7097f9e7
                Copyright © © 2020
                License:

                http://onlinelibrary.wiley.com/termsAndConditions#vor

                http://doi.wiley.com/10.1002/tdm_license_1.1

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