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      The human glucocorticoid receptor: Molecular basis of biologic function

      , , , ,

      Steroids

      Elsevier BV

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          Abstract

          The characterization of the subfamily of steroid hormone receptors has enhanced our understanding of how a set of hormonally derived lipophilic ligands controls cellular and molecular functions to influence development and help achieve homeostasis. The glucocorticoid receptor (GR), the first member of this subfamily, is a ubiquitously expressed intracellular protein, which functions as a ligand-dependent transcription factor that regulates the expression of glucocorticoid-responsive genes. The effector domains of the GR mediate transcriptional activation by recruiting coregulatory multi-subunit complexes that remodel chromatin, target initiation sites, and stabilize the RNA-polymerase II machinery for repeated rounds of transcription of target genes. This review summarizes the basic aspects of the structure and actions of the human (h) GR, and the molecular basis of its biologic functions.

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          Author and article information

          Journal
          Steroids
          Steroids
          Elsevier BV
          0039128X
          January 2010
          January 2010
          : 75
          : 1
          : 1-12
          Article
          10.1016/j.steroids.2009.09.002
          2813911
          19818358
          © 2010

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