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      Reduction of 14C-Norepinephrine Metabolism in Rabbit Aorta by Vasodilators

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          In the present study, both of the major enzymes, monoamine oxidase and catechol- o-methyltransferase, involved in the degradation of norepinephrine were examined indirectly in segments of rabbit aorta by exposure of tissues to <sup>14</sup>C-norepinephrine and subsequent isolation of metabolites from homogenates by chromatographic techniques. Segments of aorta were preincubated with vasodilators to examine their influence on accumulation and metabolism of <sup>14</sup>C-noreρinephrine. The accumulation of labeled norepinephrine by aortae was enhanced after pre-incubation with hydrochlorothiazide or diazoxide, and reduced after preincubation with sodium nitroprusside or nitroglycerin. However, the fraction of accumulated <sup>14</sup>C-norepinephrine which was degraded was significantly reduced after exposure to all four vasodilators. These results suggest that a decrease in degradation of norepinephrine in vascular smooth muscle can be observed (1) in vitro and (2) fairly rapidly after exposure to vasodilators.

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          Author and article information

          J Vasc Res
          Journal of Vascular Research
          S. Karger AG
          18 September 2008
          : 13
          : 1-2
          : 48-57
          Department of Pharmacology, Medical College of Virginia, Virginia Commonwealth University, Richmond, Va.
          158078 Blood Vessels 1976;13:48–57
          © 1976 S. Karger AG, Basel

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          Pages: 10
          Research Paper


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