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      Reduction of 14C-Norepinephrine Metabolism in Rabbit Aorta by Vasodilators

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          Abstract

          In the present study, both of the major enzymes, monoamine oxidase and catechol- o-methyltransferase, involved in the degradation of norepinephrine were examined indirectly in segments of rabbit aorta by exposure of tissues to <sup>14</sup>C-norepinephrine and subsequent isolation of metabolites from homogenates by chromatographic techniques. Segments of aorta were preincubated with vasodilators to examine their influence on accumulation and metabolism of <sup>14</sup>C-noreρinephrine. The accumulation of labeled norepinephrine by aortae was enhanced after pre-incubation with hydrochlorothiazide or diazoxide, and reduced after preincubation with sodium nitroprusside or nitroglycerin. However, the fraction of accumulated <sup>14</sup>C-norepinephrine which was degraded was significantly reduced after exposure to all four vasodilators. These results suggest that a decrease in degradation of norepinephrine in vascular smooth muscle can be observed (1) in vitro and (2) fairly rapidly after exposure to vasodilators.

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          Author and article information

          Journal
          JVR
          J Vasc Res
          10.1159/issn.1018-1172
          Journal of Vascular Research
          S. Karger AG
          1018-1172
          1423-0135
          1976
          1976
          18 September 2008
          : 13
          : 1-2
          : 48-57
          Affiliations
          Department of Pharmacology, Medical College of Virginia, Virginia Commonwealth University, Richmond, Va.
          Article
          158078 Blood Vessels 1976;13:48–57
          10.1159/000158078
          © 1976 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 10
          Categories
          Research Paper

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