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      Abnormalities in Growth Hormone and Insulin Release in Short but Otherwise Normal Patients

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          Abstract

          Arginine-insulin stimulation and IV glucose suppression (AIGT) tests were used to evaluate release of insulin and growth hormone. Adult patients responded normally. Hypopituitary patients showed no hGH response. One third of short normal patients showed abnormal hGH responses to glucose suppression. Two thirds of the short normal patients showed poor insulin responses to either amino acid or glucose stimulation. Such patients might have abnormalities in release mechanisms for insulin and suppression mechanisms for hGH and this might contribute to their growth failure.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          1663-2818
          1663-2826
          1977
          1977
          25 November 2008
          : 8
          : 2
          : 93-98
          Affiliations
          Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Md.
          Article
          178785 Horm Res 1977;8:93–98
          10.1159/000178785
          908554
          © 1977 S. Karger AG, Basel

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          Pages: 6
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