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Building up the inactive X chromosome.

Biology of the Cell

X Chromosome Inactivation, metabolism, genetics, X Chromosome, RNA, Untranslated, RNA, Long Noncoding, Nucleic Acid Conformation, Male, Humans, Gene Silencing, Female, Epigenesis, Genetic, Dosage Compensation, Genetic, chemistry, Chromatin, Animals

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      Abstract

      The compensation of the different level of transcripts of X-linked genes in male and female mammals is achieved through X chromosome inactivation, a complex process that differentially regulates the sex chromosomes of female cells. This mechanism has been dissected at evolutionary, genetic and molecular levels: here, we discuss some of the latest examples that illustrate better these intricate connections, focusing particularly on the emerging role of spatial and three-dimensional chromatin arrangements in the building of this special chromosome, the inactive X chromosome.

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      Journal
      10.1042/BC20070073
      18072943

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