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      Evaluation of Serotonin Levels in Human Aqueous Humor


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          Purpose: Serotonin is biochemically present in the iris and ciliary body of animals and humans. Controversial findings are reported about the concentrations of serotonin in aqueous humor with respect to plasma in humans. The aim of this study was to evaluate the levels of serotonin both in aqueous humor and plasma in human subjects. Methods: In 50 patients with glaucoma or cataract, plasma and aqueous humor serotonin levels were measured by HPLC with electrochemical detection. Serotonin plasma levels were also measured in 25 healthy subjects as controls. Results: In all patients with cataract or glaucoma, the aqueous humor serotonin concentration is significantly lower than that in plasma [1.14±0.29 (SEM) vs. 5.33±1.03 ng/ml, p < 0.01]. Furthermore, in the same patients and in 25 healthy controls, serotonin plasma levels were similar. Conclusion: Our study shows that serotonin is present in human aqueous humor and its concentration is 4 times lower than in plasma.

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          Most cited references2

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          Receptor binding profile of R 41 468, A novel antagonist at 5-HT2 receptors

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            • Article: not found

            The occurrence of serotonergic nerves in the bovine cornea.

            Using high performance liquid chromatography (HPLC) and electrochemical detection, serotonin and its precursor 5-hydroxytryptophan (5-HTP) were identified in crude perchloric acid extracts from bovine cornea. In addition, dopamine, noradrenaline and adrenaline were identified. Through the use of immunohistochemical procedures it was established that the serotonin is localized in nerve fibers in the cornea and they were always found subepithelially or in the stroma. The occurrence of serotonergic fibres in the cornea suggests that the amine has a specific functional role in this tissue.

              Author and article information

              S. Karger AG
              June 1998
              19 March 1998
              : 212
              : 3
              : 160-163
              aDepartment of Medicine and Experimental Oncology and bEye Clinic, University of Turin, Italy
              27268 Ophthalmologica 1998;212:160–163
              © 1998 S. Karger AG, Basel

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              Page count
              Figures: 2, References: 19, Pages: 4
              Original Paper · Travail original · Originalarbeit

              Vision sciences,Ophthalmology & Optometry,Pathology
              Cataract,Human aqueous humor,Glaucoma,Serotonin
              Vision sciences, Ophthalmology & Optometry, Pathology
              Cataract, Human aqueous humor, Glaucoma, Serotonin


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