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      Evaluation of Serotonin Levels in Human Aqueous Humor

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          Abstract

          Purpose: Serotonin is biochemically present in the iris and ciliary body of animals and humans. Controversial findings are reported about the concentrations of serotonin in aqueous humor with respect to plasma in humans. The aim of this study was to evaluate the levels of serotonin both in aqueous humor and plasma in human subjects. Methods: In 50 patients with glaucoma or cataract, plasma and aqueous humor serotonin levels were measured by HPLC with electrochemical detection. Serotonin plasma levels were also measured in 25 healthy subjects as controls. Results: In all patients with cataract or glaucoma, the aqueous humor serotonin concentration is significantly lower than that in plasma [1.14±0.29 (SEM) vs. 5.33±1.03 ng/ml, p < 0.01]. Furthermore, in the same patients and in 25 healthy controls, serotonin plasma levels were similar. Conclusion: Our study shows that serotonin is present in human aqueous humor and its concentration is 4 times lower than in plasma.

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          Most cited references2

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          Receptor binding profile of R 41 468, A novel antagonist at 5-HT2 receptors

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            The occurrence of serotonergic nerves in the bovine cornea.

            Using high performance liquid chromatography (HPLC) and electrochemical detection, serotonin and its precursor 5-hydroxytryptophan (5-HTP) were identified in crude perchloric acid extracts from bovine cornea. In addition, dopamine, noradrenaline and adrenaline were identified. Through the use of immunohistochemical procedures it was established that the serotonin is localized in nerve fibers in the cornea and they were always found subepithelially or in the stroma. The occurrence of serotonergic fibres in the cornea suggests that the amine has a specific functional role in this tissue.
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              Author and article information

              Journal
              OPH
              Ophthalmologica
              10.1159/issn.0030-3755
              Ophthalmologica
              S. Karger AG
              0030-3755
              1423-0267
              1998
              June 1998
              19 March 1998
              : 212
              : 3
              : 160-163
              Affiliations
              aDepartment of Medicine and Experimental Oncology and bEye Clinic, University of Turin, Italy
              Article
              27268 Ophthalmologica 1998;212:160–163
              10.1159/000027268
              9562088
              7cf9eb72-1337-49e2-9c79-1f1ce587f972
              © 1998 S. Karger AG, Basel

              Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

              History
              Page count
              Figures: 2, References: 19, Pages: 4
              Categories
              Original Paper · Travail original · Originalarbeit

              Vision sciences,Ophthalmology & Optometry,Pathology
              Cataract,Human aqueous humor,Glaucoma,Serotonin
              Vision sciences, Ophthalmology & Optometry, Pathology
              Cataract, Human aqueous humor, Glaucoma, Serotonin

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