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      Bamboo salt suppresses skin inflammation in mice with 2, 4-dinitrofluorobenzene-induced atopic dermatitis

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          Abstract

          Bamboo salt (BS) is a traditional Korean food, and has been reported to have anti-cancer, anti-inflammatory, and anti-metastatic effects. However, the anti-atopic dermatitis (AD) activity of BS has not been described yet. In the present study, we examined the preventive effect of BS on AD. The effect of oral administration of BS was tested in a 2, 4-dinitrofluorobenzene (DNFB)-induced AD animal model, by histological analysis, enzyme-linked immunosorbent assay, reverse transcription-polymerase chain reaction, caspase-1 assay, and Western blotting analysis. BS administration reduced the total clinical severity and scratching frequencies, compared with the AD group. In the serum of DNFB-induced AD mice, the levels of IgE, histamine, thymic stromal lym-phopoietin (TSLP), interleukin (IL)-5, and IL-13 were significantly reduced by BS treatment. BS significantly reduced the protein and mRNA expression of TSLP, IL-6, and tumor necrosis factor-α in the AD skin lesions. BS markedly reduced the infiltration of inflammatory cells. Furthermore, the activation of caspase-1 was reduced by BS in the AD skin lesions. Our results suggested that BS should be considered as a candidate treatment for allergic inflammatory diseases including AD.

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          Author and article information

          Journal
          CJNM
          Chinese Journal of Natural Medicines
          Elsevier
          1875-5364
          20 February 2018
          : 16
          : 2
          : 97-104
          Affiliations
          1Department of Pharmacology, College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of Korea
          2Department of Biotechnology, Hoseo University, Chungcheongnam-do 31499, Republic of Korea
          3Department of Food Science & Technology and Research Institute for Basic Science, Hoseo University, Chungcheongnam-do 31499, Republic of Korea
          Author notes
          *Corresponding authors: Hyung-Min Kim, Tel: 82-2-961-9448, Fax: 82-2-967-7707, E-mails: hmkim@ 123456khu.ac.kr , Hyun-Ja Jeong, Tel: 82-41-540-9681, Fax: 82-41-542-9681, hjjeong@ 123456hoseo.edu

          These authors have no conflict of interest to declare.

          Article
          S1875-5364(18)30035-9
          10.1016/S1875-5364(18)30035-9
          Copyright © 2018 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.
          Funding
          Funded by: Ministry of Education, Science and Technology
          Award ID: 2015R1D1A1A01056607
          This work was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (No. 2015R1D1A1A01056607).

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