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Abstract
Immunohistological analysis of tissue sections from human brain revealed that intercellular
adhesion molecule-1 (ICAM-1) is mainly expressed on endothelial cells of small vessels,
including the subependymal vessels of the choroid plexus. In addition, it is expressed
on cerebrospinal fluid (CSF) cells in patients with inflammatory diseases of the central
nervous system. Stimulation of confluent monolayers of adult human cerebral endothelial
cells with lipopolysaccharide (LPS) or recombinant human tumor necrosis factor-alpha
(TNF-alpha) could induce expression and secretion of soluble ICAM-1 in a dose dependent
manner. In addition, sICAM-1 was also present in the supernatant from U251 glioma
cells. No sICAM was detected in the culture supernatant from activated blood or CSF
lymphocytes. Cerebral endothelial cells are therefore a likely source for sICAM-1
in the CSF.