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      Endocrinological Environment of Polycystic Ovarian Disease


      Hormone Research in Paediatrics

      S. Karger AG

      Gonadotropins, PRL, PCOD, Dopamine, Metoclopramide

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          Serum levels of androgenic hormones, 17-hydroxyprogesterone and estrone in Japanese patients with polycystic ovarian disease (PCOD) were elevated as compared to normal women. In early follicular phase of all of PCOD patients, serum levels LH were always higher than those of FSH. Serum PRL levels were shown to be significantly (p < 0.05) higher in PCOD patients than in normal women. Although the cause of both inappropriate gonadotropin secretion and occurrence of mild hyperprolactinemia in PCOD have not been fully elucidated, decrease in numbers of receptor for dopamine is thought to be one of the main causes of them from the present data obtained by metoclopramide injection administered during the continuous infusion of dopamine.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          02 December 2008
          : 33
          : Suppl 2
          : 5-9
          Department of Obstetrics and Gynecology, Hokkaido University School of Medicine, Sapporo, Japan
          181557 Horm Res 1990;33:5–9
          © 1990 S. Karger AG, Basel

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          Page count
          Pages: 5
          New Aspects of Pathophysiology and Treatment of Polycystic Ovary Syndrome


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