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      Improving oncologic outcomes for colorectal cancer at high risk for local-regional recurrence with novel surgical techniques.

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          Abstract

          Despite innovation in surgical technology, colorectal adenocarcinoma is a disease process with a risk of local and regional progression of disease. This article seeks to identify patients with primary disease who are at high risk for minimal residual disease from cancer spread after resection. These are the patients who will profit from novel perioperative surgical treatments that will improve the clearance and containment of cancer cells disseminated prior to or at the time of the adenocarcinoma resection. Clinical factors that identify these patients at high risk for local recurrence and peritoneal metastases are presented. Data regarding novel surgical techniques that include perioperative cancer chemotherapy to provide more optimal treatment are described. The perioperative timing of the revised surgical options is emphasized.

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          Author and article information

          Journal
          Expert Rev Gastroenterol Hepatol
          Expert review of gastroenterology & hepatology
          Informa UK Limited
          1747-4132
          1747-4124
          2016
          : 10
          : 2
          Affiliations
          [1 ] a Center for Gastrointestinal Malignancies , MedStar Washington Hospital Center , Washington , DC , USA.
          Article
          10.1586/17474124.2016.1110019
          26643935
          7d2ada1e-d449-415a-811f-1a20cf2db56c
          History

          intraperitoneal chemotherapy,local recurrence,hyperthermia,cytoreductive surgery,colorectal cancer,carcinomatosis,Peritoneal metastases,HIPEC,EPIC

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