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      Angiotensin I Converting Enzyme Activity in Rabbit Corneal Endothelial Cells

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          Abstract

          Angiotensin I converting enzyme (ACE) was studied in Vero cells, rabbit corneal fibroblasts, and rabbit corneal endothelial cells. The enzyme activity was determined by means of an assay employing hippuryl-glycyl-glycine as a substrate. The hippuric acid end product was separated from the substrate by reversed phase liquid chromatography and measured spectrophotometrically at 228 nm. The enzyme was further characterized by a captopril inhibition study. Significant ACE activity was found in rabbit corneal endothelial cells but not in other types of cells tested. This is the first report of the presence of this enzyme in a specific ocular cell type and suggests that angiotensin II may play a role in normal ocular physiology.

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          Author and article information

          Journal
          OPH
          Ophthalmologica
          10.1159/issn.0030-3755
          Ophthalmologica
          S. Karger AG
          978-3-8055-3758-2
          978-3-318-05669-3
          0030-3755
          1423-0267
          1983
          1983
          31 March 2010
          : 187
          : 2
          : 129-132
          Affiliations
          aInstitute of Ophthalmology bDepartment of Microbiology and eDepartment of Medical Biochemistry, University of Antwerp, UIA, Wilrijk, Belgium
          Article
          309311 Ophthalmologica 1983;187:129–132
          10.1159/000309311
          6310465
          7d2fdc28-6c4d-480f-baa6-076085669ff3
          © 1983 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          : 06 December 1982
          : 21 December 1982
          Page count
          Pages: 4
          Categories
          Intraocular Lenses and Corneal Endothelium

          Vision sciences,Ophthalmology & Optometry,Pathology
          Corneal endothelial cells,Enzyme activity
          Vision sciences, Ophthalmology & Optometry, Pathology
          Corneal endothelial cells, Enzyme activity

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