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      Immune Complex Nephritis in Nude Mice

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          Abstract

          To examine the effect of T lymphocyte deficiency on the course of immune complex nephritis, we studied renal function and structure in Swissalbino nude and non-nude mice following injection of heterologous protein. Four groups of 22 mice each (two nude and two non-nude) received either apoferritin 2 mg or saline daily for 10 weeks. Nude mice were maintained in a gnotobiotic environment. Non-nude mice receiving apoferritin developed proteinuria and had increased cellularity within glomeruli compared to either nude mice receiving apoferritin or to control groups (p < 0.05). Of 22 non-nude mice receiving apoferritin, 16 had glomerular immune deposits by electron and immunofluorescent microscopy while 9 of 22 counterpart nude mice receiving apoferritin had such deposits. Non-nude mice more commonly showed membraneous deposits. Nude and non-nude mice receiving saline had no glomerular deposits. These preliminary data suggest that T lymphocytes may play a significant role in the development of immune complex nephritis.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1981
          1981
          03 December 2008
          : 29
          : 1-2
          : 95-98
          Affiliations
          Departments of Medicine and Pathology, Indiana University School of Medicine, Indianapolis, Ind., USA
          Article
          182247 Nephron 1981;29:95–98
          10.1159/000182247
          6460198
          © 1981 S. Karger AG, Basel

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          Page count
          Pages: 4
          Categories
          Original Paper

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