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      Histopathologic findings in a novel decellularized pulmonary homograft: an autopsy study.

      The Annals of thoracic surgery
      Autopsy, Fatal Outcome, Heart Valve Prosthesis Implantation, Humans, Macrophages, pathology, Male, Middle Aged, Pulmonary Valve Stenosis, surgery, Transplantation, Homologous

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          Abstract

          Innovative valved conduits for reconstruction of the right ventricular outflow tract are desirable to overcome the risk of valve deterioration of conventional homografts. This study describes the histopathology of a novel decellularized pulmonary homograft (SynerGraft) implanted in the right ventricular outflow tract of a 60-year-old man 5 weeks before death. The histomorphology of this decellularized homograft showed integrity of its extracellular matrix and a gradual cellular infiltrate consisting predominantly of macrophages, resembling an early nonspecific inflammatory phase of recellularization without any signs of a specific immunologic interference 5 weeks after implantation. Whether this morphologic appearance precedes the desired repopulation with autologous fibroblasts remains to be established.

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          Author and article information

          Journal
          15854972
          10.1016/j.athoracsur.2003.11.049

          Chemistry
          Autopsy,Fatal Outcome,Heart Valve Prosthesis Implantation,Humans,Macrophages,pathology,Male,Middle Aged,Pulmonary Valve Stenosis,surgery,Transplantation, Homologous

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