27
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      In vitro models of molecular and nano-particle transport across the blood-brain barrier

      other

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The blood-brain barrier (BBB) is the tightest endothelial barrier in humans. Characterized by the presence of tight endothelial junctions and adherens junctions, the primary function of the BBB is to maintain brain homeostasis through the control of solute transit across the barrier. The specific features of this barrier make for unique modes of transport of solutes, nanoparticles, and cells across the BBB. Understanding the different routes of traffic adopted by each of these is therefore critical in the development of targeted therapies. In an attempt to move towards controlled experimental assays, multiple groups are now opting for the use of microfluidic systems. A comprehensive understanding of bio-transport processes across the BBB in microfluidic devices is therefore necessary to develop targeted and efficient therapies for a host of diseases ranging from neurological disorders to the spread of metastases in the brain.

          Related collections

          Author and article information

          Contributors
          Journal
          Biomicrofluidics
          Biomicrofluidics
          BIOMGB
          Biomicrofluidics
          AIP Publishing LLC
          1932-1058
          31 May 2018
          July 2018
          : 12
          : 4
          : 042213
          Affiliations
          [1 ] Department of Mechanical Engineering, Massachusetts Institute of Technology , 500 Technology Square, MIT Building, Room NE47-321, Cambridge, Massachusetts 02139, USA
          [2 ] Department of Mechanical and Aerospace Engineering , Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Turin, Italy
          [3 ] Department of Biological Engineering, Massachusetts Institute of Technology , 500 Technology Square, MIT Building, Room NE47-321, Cambridge, Massachusetts 02139, USA
          [4 ] Singapore-MIT Alliance for Research and Technology (SMART), BioSystems and Micromechanics (BioSym) , Singapore, Singapore
          Author notes
          [a) ]Author to whom correspondence should be addressed: valeria.chiono@ 123456polito.it and rdkamm@ 123456mit.edu
          Author information
          http://orcid.org/0000-0002-0361-6703
          http://orcid.org/0000-0002-3969-8771
          http://orcid.org/0000-0003-2067-7732
          http://orcid.org/0000-0002-7232-304X
          Article
          PMC5980570 PMC5980570 5980570 1.5027118 013891BMF BTPMD-18098R
          10.1063/1.5027118
          5980570
          29887937
          7d6d9f27-8aa3-49c9-a36f-5286c35c67dd
          Copyright © 2018 Author(s)

          Published by AIP Publishing.

          1932-1058/2018/12(4)/042213/31/ $30.00

          History
          : 27 February 2018
          : 09 May 2018
          Page count
          Pages: 31
          Funding
          Funded by: National Cancer Institute http://dx.doi.org/10.13039/100000054
          Award ID: U01 CA202177
          Funded by: H2020 Marie Skłodowska-Curie Actions http://dx.doi.org/10.13039/100010665
          Award ID: No. 658665
          Categories
          SPECIAL TOPIC: BIO-TRANSPORT PROCESSES AND DRUG DELIVERY IN PHYSIOLOGICAL MICRO-DEVICES
          Contributed Articles
          Custom metadata

          Comments

          Comment on this article