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      In vitro models of molecular and nano-particle transport across the blood-brain barrier.

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          Abstract

          The blood-brain barrier (BBB) is the tightest endothelial barrier in humans. Characterized by the presence of tight endothelial junctions and adherens junctions, the primary function of the BBB is to maintain brain homeostasis through the control of solute transit across the barrier. The specific features of this barrier make for unique modes of transport of solutes, nanoparticles, and cells across the BBB. Understanding the different routes of traffic adopted by each of these is therefore critical in the development of targeted therapies. In an attempt to move towards controlled experimental assays, multiple groups are now opting for the use of microfluidic systems. A comprehensive understanding of bio-transport processes across the BBB in microfluidic devices is therefore necessary to develop targeted and efficient therapies for a host of diseases ranging from neurological disorders to the spread of metastases in the brain.

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          Author and article information

          Journal
          Biomicrofluidics
          Biomicrofluidics
          AIP Publishing
          1932-1058
          1932-1058
          Jul 2018
          : 12
          : 4
          Affiliations
          [1 ] Department of Mechanical Engineering, Massachusetts Institute of Technology, 500 Technology Square, MIT Building, Room NE47-321, Cambridge, Massachusetts 02139, USA.
          [2 ] Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Turin, Italy.
          Article
          1.5027118 013891BMF
          10.1063/1.5027118
          5980570
          29887937

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