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      Ectopic ACTH Syndrome: Discrepancy between Somatostatin Receptor Status in vivo and ex vivo, and between Immunostaining and Gene Transcription for POMC and CRH

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          Objective: To characterize somatostatin receptor status in vivo and ex vivo and immunoreactivity and gene transcription for proopiomelanocortin (POMC) and corticotropin-releasing hormone (CRH) in a case of Cushing’s syndrome caused by a sporadic metastatic medullary thyroid carcinoma (MTC). Methods:<sup>111</sup>In octreoscan, analysis of tumorous mRNA transcripts for somatostatin receptor subtypes (SSTR) as well as for POMC and CRH. Results: The tissue was intensely positive by <sup>111</sup>In octreoscan but expressed only SSTR 1, 3 and 5. There was immunopositivity only for CRH, but gene transcription for both POMC and CRH was seen. Conclusions: (1) This first comparison between somatostatin receptor status in vivo and ex vivo in MTC shows a marked positive octreoscan despite absent SSTR 2 expression, and (2) this is the first report of a discrepancy between immunostaining and gene transcription for POMC and CRH.

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          The Diagnosis and Differential Diagnosis of Cushing's Syndrome and Pseudo-Cushing's States

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            Gene Transcription of Receptors for Growth Hormone-Releasing Peptide and Somatostatin in Human Pituitary Adenomas

             S. NIELSEN,  S Nielsen (1998)

              Author and article information

              Horm Res Paediatr
              Hormone Research in Paediatrics
              S. Karger AG
              30 May 2002
              : 57
              : 5-6
              : 200-204
              aDepartment of Endocrinology and Metabolism, bLaboratory for Molecular Pathology, cDepartment of Nuclear Medicine, and dMedical Department M (Endocrinology and Diabetes), Aarhus University Hospital, Aarhus, Denmark; eDepartment of Pathology, University of Toronto, Ont., Canada
              58383 Horm Res 2002;57:200–204
              © 2002 S. Karger AG, Basel

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              Page count
              Figures: 3, Tables: 1, References: 11, Pages: 5
              Case Report


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