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      Effects of Dietary Protein on the Progression of Renal Failure in the Fawn-Hooded Rat

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          Abstract

          Fawn-Hooded (FH) rats on a normal protein intake develop focal glomerulosclerosis, proteinuria and hypertension and die prematurely because of renal failure. In the present study we examined the effect of a life long feeding of a low (12%)-protein (LP) diet and a high (36%)-protein (HP) diet on renal function, urinary protein excretion (U<sub>prot</sub>V), systolic blood pressure (SBP) and survival time. Compared to the LP diet, the HP diet initially raised the glomerular filtration rate (GFR) and the U<sub>prot</sub>V, while the SBP was about the same. The U<sub>prot</sub>V of rats on the HP diet increased steadily and the GFR started to decline after 40 weeks. The LP diet resulted in a prolonged period of stable renal function, limited proteinuria and an increased life span. In the 2nd year of life, the level of hypertension was less in FH rats on the HP diet. Throughout the study there was no relationship between the SBP and the U<sub>prot</sub>V. The low UprotV in FH rats on the LP diet points to a lower level of glomerular capillary pressure. The attenuated development of glomerular hypertension on the LP diet slows down the subsequent renal damage in FH rats. This is in agreement with the view that glomerular hypertension is an essential hemodynamic derangement responsible for progressive deterioration of glomerular function. As in other rat models, i.e. renal ablation or unilateral nephrectomy, the LP diet slowed down the development of renal failure but did not prevent it.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1990
          1990
          10 December 2008
          : 55
          : 2
          : 203-209
          Affiliations
          Department of Pediatric Surgery, Erasmus University Medical School, Rotterdam, The Netherlands
          Article
          185953 Nephron 1990;55:203–209
          10.1159/000185953
          2362635
          © 1990 S. Karger AG, Basel

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          Page count
          Pages: 7
          Categories
          Original Paper

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