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      Calcinosis and Metastatic Calcification due to Vitamin D Intoxication

      a , b

      Hormone Research in Paediatrics

      S. Karger AG

      Vitamin D, Calcinosis, Hypoparathyroidism

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          Vitamin D, a fat-soluble vitamin, can be associated with significant morbidity when prescribed in large doses. We describe a hypoparathyroid patient with vitamin D intoxication who developed painful periarticular calcinosis, nephrocalcinosis with hypertension and chronic renal failure in addition to band keratopathy and hearing loss. He was treated with combination therapy including prednisone, phosphate-binding antacid, phenytoin and disodium etidronate. After 20 months of follow-up there was a significant reduction of periarticular calcinosis, but no improvement in renal function, band keratopathy or hearing loss and possible calcification of the ossicles. The clinicopathologic features of metastatic calcification and the various treatment modalities are reviewed.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          03 December 2008
          : 37
          : 1-2
          : 68-77
          aCosmopolitan International Diabetes Center, University of Missouri-Columbia School of Medicine, and Harry S. Truman Memorial Veterans Hospital, Columbia, Mo.; bVeteran Affairs Medical Center and University of Arizona, Tucson, Ariz., USA
          182285 Horm Res 1992;37:68–77
          © 1992 S. Karger AG, Basel

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          Pages: 10
          Case Report


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