95
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Tumor spectrum analysis in p53-mutant mice.

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The p53 tumor suppressor gene is mutated in a large percentage of human malignancies, including tumors of the colon, breast, lung and brain. Individuals who inherit one mutant allele of p53 are susceptible to a wide range of tumor types. The gene encodes a transcriptional regulator that may function in the cellular response to DNA damage. The construction of mouse strains carrying germline mutations of p53 facilitates analysis of the function of p53 in normal cells and tumorigenesis.

          Related collections

          Author and article information

          Journal
          Curr Biol
          Current biology : CB
          Elsevier BV
          0960-9822
          0960-9822
          Jan 01 1994
          : 4
          : 1
          Affiliations
          [1 ] Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139.
          Article
          S0960-9822(00)00002-6
          10.1016/s0960-9822(00)00002-6
          7922305
          7db2512f-ef69-4117-91cc-4f2281981a0d
          History

          Comments

          Comment on this article