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      Production of biologically active human lymphotactin (XCL1) by Lactococcus lactis.

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          Abstract

          Lymphotactin-XCL1 is a chemokine produced mainly by activated CD8+ T-cells and directs migration of CD4+ and CD8+ lymphocytes and natural killer (NK) cells. We expressed human lymphotactin (LTN) by the lactic-acid bacterium Lactococcus lactis. Biological activity of LTN was confirmed by chemo-attraction of human T-cells by chemotaxis demonstrating, for the first time, how this chemokine secreted by a food-grade prokaryote retains biological activity and chemoattracts T lymphocytes. This strain thus represents a feasible well-tolerated vector to deliver active LTN at a mucosal level.

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          Author and article information

          Journal
          Biotechnol. Lett.
          Biotechnology letters
          1573-6776
          0141-5492
          Feb 2009
          : 31
          : 2
          Affiliations
          [1 ] Departamento de Histología, Facultad de Medicina, Universidad Autónoma de Nuevo León, Monterrey, NL, Mexico.
          Article
          10.1007/s10529-008-9855-6
          18923910

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