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      Platelet count as useful indicator for gram-type of bacteria causing urinary tract infection in women Translated title: El recuento de plaquetas como indicador útil de bacterias tipo Gram que causan infecciones del tracto urinario en mujeres

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          Abstract

          Abstract Introduction: Urinary Tract infection (UTI) is considered as the most common infections disease among women. UTI may lead to a serious complication in both kidneys. In this study, we tried to determine whether the alternation in platelet count during UTI is related to specific Gram-type of bacteria causing the infection. This assists the medical staff in selection of suitable antimicrobial drug. Material and Methods: Data of all urine cultures from Gynecology Department/ Albaraa Hospital/Tripoli processed at the Laboratory during a period of three years (2017 - 2019). All Data analysis and statistics were made with the SPSS software version 16 and performed with one-way ANOVA and a parametric test was used for categorical values and not normally distributed values. Results: A growth was detected in 101 of 193 (52%) samples and 22 (11%) were mixed growth. Gram-negative bacteria identified in 57% (45/79) while 43% (34/79) occurred with Gram-positive bacteria. Regarding to platelets count alteration, it is revealed that there was a significant difference between cases infected by Gram-negative bacteria compared to others infected by Gram-positive bacteria and control group. Conclusions: Results of the current study suggest that the change in platelet count during UTI is associated with causative bacteria’s Gram-type.

          Translated abstract

          Resumen Introducción: La infección del tracto urinario (ITU) se considera la enfermedad infecciosa más común entre las mujeres. La ITU puede provocar una complicación grave en ambos riñones. En este estudio, intentamos determinar si la alternancia en el recuento de plaquetas durante la ITU está relacionada con el tipo específico de bacterias Gram que causan la infección. Esto ayuda al personal médico a seleccionar el fármaco antimicrobiano adecuado. Material y Métodos: Datos de todos los urocultivos del Servicio de Ginecología del Hospital Albaraa (Trípoli), procesados en el Laboratorio durante un período de tres años (2017-2019). Todos los análisis de datos y estadísticas se realizaron con el software SPSS versión 16 y se realizaron con ANOVA de una vía y se utilizó una prueba paramétrica para valores categóricos y valores no distribuidos normalmente. Resultados: Se detectó un crecimiento en 101 de 193 (52%) muestras y 22 (11%) fueron de crecimiento mixto. Las bacterias Gram negativas se identificaron en el 57% (45/79) mientras que el 43% (34/79) se presentaron con bacterias Gram positivas. En cuanto a la alteración del recuento de plaquetas, se revela que hubo una diferencia significativa entre los casos infectados por bacterias Gram negativas frente a otros infectados por bacterias Gram positivas y el grupo control. Conclusiones: Los resultados del estudio actual sugieren que el cambio en el recuento de plaquetas durante la ITU está asociado con el tipo Gram de la bacteria causante.

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          Most cited references26

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          International clinical practice guidelines for the treatment of acute uncomplicated cystitis and pyelonephritis in women: A 2010 update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases.

          A Panel of International Experts was convened by the Infectious Diseases Society of America (IDSA) in collaboration with the European Society for Microbiology and Infectious Diseases (ESCMID) to update the 1999 Uncomplicated Urinary Tract Infection Guidelines by the IDSA. Co-sponsoring organizations include the American Congress of Obstetricians and Gynecologists, American Urological Association, Association of Medical Microbiology and Infectious Diseases-Canada, and the Society for Academic Emergency Medicine. The focus of this work is treatment of women with acute uncomplicated cystitis and pyelonephritis, diagnoses limited in these guidelines to premenopausal, non-pregnant women with no known urological abnormalities or co-morbidities. The issues of in vitro resistance prevalence and the ecological adverse effects of antimicrobial therapy (collateral damage) were considered as important factors in making optimal treatment choices and thus are reflected in the rankings of recommendations.
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            The challenge of emerging and re-emerging infectious diseases

            Infectious diseases have for centuries ranked with wars and famine as major challenges to human progress and survival. They remain among the leading causes of death and disability worldwide. Against a constant background of established infections, epidemics of new and old infectious diseases periodically emerge, greatly magnifying the global burden of infections. Studies of these emerging infections reveal the evolutionary properties of pathogenic microorganisms and the dynamic relationships between microorganisms, their hosts and the environment.
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              Acute-phase proteins: As diagnostic tool

              The varied reactions of the host to infection, inflammation, or trauma are collectively known as the acute-phase response and encompass a wide range of pathophysiological responses such as pyrexia, leukocytosis, hormone alterations, and muscle protein depletion combining to minimize tissue damage while enhancing the repair process. The mechanism for stimulation of hepatic production of acute-phase proteins is by proinflammatory cytokines. The functions of positive acute-phase proteins (APP) are regarded as important in optimization and trapping of microorganism and their products, in activating the complement system, in binding cellular remnants like nuclear fractions, in neutralizing enzymes, scavenging free hemoglobin and radicals, and in modulating the host’s immune response. APP can be used as diagnostic tool in many diseases like bovine respiratory syncytial virus, prostate cancer, bronchopneumonia, multiple myeloma, mastitis, Streptococcus suis infection, starvation, or lymphatic neoplasia. Thus, acute-phase proteins may provide an alternative means of monitoring animal health.
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                Author and article information

                Journal
                ijm
                Iberoamerican Journal of Medicine
                Iberoam J Med
                Hospital San Pedro (Logroño, La Rioja, Spain )
                2695-5075
                2695-5075
                2022
                : 4
                : 1
                : 24-29
                Affiliations
                [4] Tripoli orgnameAlbraraa Hospital Libia
                [3] Tripoli orgnameBiotechnology Research Center Libia
                [1] Tripoli orgnameUniversity of Tripoli orgdiv1Faculty of Medical Technology orgdiv2Department of Laboratory Sciences Libia
                [2] Tripoli orgnameUniversity of Tripoli orgdiv1Faculty of Medical Technology orgdiv2Department of Public Health Libia
                Article
                S2695-50752022000100005 S2695-5075(22)00400100005
                10.53986/ibjm.2022.0006
                7dd31a80-3c60-479e-a81b-b9c92e07158a

                This work is licensed under a Creative Commons Attribution 4.0 International License.

                History
                : 19 December 2021
                : 23 October 2021
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 26, Pages: 6
                Product

                SciELO Spain

                Categories
                Original Article

                Bacteria,Recuento de plaquetas,Mujer,Infección del tracto urinario,Gram-type,Platelet count,Women,Urinary tract infection,Gram-tipo

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