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      Hemodynamic Response to Glyceryl Trinitrate in a Spray at Rest and during Exercise in a Sitting Position

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      Cardiology

      S. Karger AG

      Glyceryl trinitrate, Hemodynamics, Coronary artery disease

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          Abstract

          Glyceryl trinitrate (GNT, 0.8 mg) was administered in a spray to 15 coronary patients of whom 7 had a pulmonary wedge pressure (PWP) greater than 16 mm Hg on exercise (subgroup I) and the others (subgroup II) had a normal PWP at rest and during exercise. At rest, GNT increased heart rate and decreased cardiac output, systolic index, stroke work index, right atrial pressure, pulmonary wedge and mean systemic pressures in all patients. Peripheral resistances did not change. During exercise, GNT lowered PWP, systemic arterial pressure and peripheral resistances in all cases. It increased cardiac output as well as systolic and stroke work indices only in patients of subgroup I. In subjects with coronary disease, no overt cardiac failure but elevated PWP on exercise, GNT in a spray can quickly improve exercise capacity and hemodynamic reserves and increase anginal threshold.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          0008-6312
          1421-9751
          1982
          1982
          07 November 2008
          : 69
          : 2
          : 84-90
          Affiliations
          Section of Cardiology, Institute of Medicine, University of Liège, Belgium
          Article
          173488 Cardiology 1982;69:84–90
          10.1159/000173488
          6809331
          © 1982 S. Karger AG, Basel

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          Page count
          Pages: 7
          Categories
          Original Paper

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