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      Development and validation of liquid chromatography–tandem mass spectrometry method for simultaneous determination of zinc pyrithione and pyrithione in shampoos

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          Abstract

          A simple, rapid, and sensitive liquid chromatography–tandem mass spectrometry (LC–MS/MS) method was developed and validated for the determination of zinc pyrithione (ZnPT) and pyrithione (PT) in shampoos. The method consisted of a liquid–liquid extraction for sample preparation. The mass spectrometer was operated in multiple reaction monitoring (MRM) mode via the positive electrospray ionization interface. A linear regression (weighted 1/ x) was used to fit calibration curves over the concentration range of 50–2000 ng/mL for both ZnPT and PT. Excellent linearity ( r 2 ≥ 0.9996) was achieved for all. The method was validated and found to be accurate (95.9–108.2% for ZnPT and 94.9–110.4% for PT), precise, and selective. Analytes in shampoos were found to be stable in the autosampler (6 °C for 6 h), in room temperature (for 6 h), and after three freeze–thaw cycles, and recovery of analytes was reproducible (90.8–94.6% for ZnPT and 90.2–96.3% for PT).

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          Author and article information

          Journal
          1326
          Acta Chromatographica
          Acta Chromatographica
          Akadémiai Kiadó
          2083-5736
          September 2018
          : 30
          : 3
          : 200-205
          Affiliations
          [ 1 ]Bioresource Regional Innovation Center, Soonchunhyang University , Soonchunhyang-ro 22, Shinchang-myun, Asan, Chungnam 31538, Republic of Korea
          [ 2 ]Department of Pharmacology, College of Medicine, Dankook University , Dandae-ro 119, Dongnam-gu, Cheonan, Chungnam 31116, Republic of Korea
          Author notes
          [*]

          Author for correspondence: hgkimm@ 123456dankook.ac.kr

          Article
          10.1556/1326.2017.00294
          © 2017 The Author(s)

          This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (https://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted use, distribution, and reproduction in any medium for non-commercial purposes, provided the original author and source are credited, a link to the CC License is provided, and changes - if any - are indicated.

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          Pages: 6
          Categories
          Original Research Paper

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