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      Fibrin- and fibrinogen-related antigens in patients with venous disease and venous ulceration.

      1 , ,

      Archives of dermatology

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          Abstract

          Abnormalities in systemic fibrinolysis have been implicated in the pathogenesis of venous ulceration. Patients with venous disease have a prolonged euglobulin lysis time and elevated plasma fibrinogen levels, yet little is known about the metabolism of fibrinogen and fibrin in such patients. In this study, we have used a technique that involves electrophoresis and densitometric analysis of captured fibrin-related antigens to measure the concentration and proportions of the individual fibrin and fibrinogen degradation products in patients with venous disease of the lower extremity. As a group, patients with venous disease had markedly elevated levels of total fibrin-related antigen and D-dimer, the terminal degradation product of cross-linked fibrin. Levels of D-monomer, the breakdown product of fibrinogen and non-cross-linked fibrin monomer, and a measure of fibrinogenolysis were normal in all patients. In patients with ulcers, the levels of D-dimer were disproportionately higher than expected from fibrin monomer levels. On an individual basis, significant elevations of D-dimer were present in six (55%) of the 11 patients with venous disease with ulcers and in three (43%) of the seven patients with venous disease without ulcers. We conclude that patients with venous disease have uniform evidence for enhanced fibrin formation, as evidenced by elevated levels of total fibrin-related antigen and D-dimer. This is regardless of whether the venous disease is accompanied by ulceration.

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          Author and article information

          Journal
          Arch Dermatol
          Archives of dermatology
          0003-987X
          0003-987X
          Jan 1991
          : 127
          : 1
          Affiliations
          [1 ] Department of Dermatology and Cutaneous Surgery, University of Miami School of Medicine, FL 33101.
          Article
          1986710
          7df8fdfc-f8b7-4ae7-9e6b-e9d0a2ed801a

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