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      High-Affinity Uptake of Hypothalamic Neurotransmitters in Mice Treated Neonatally with Monosodium Glutamate

      , ,

      Neuroendocrinology

      S. Karger AG

      GABA, Choline, Monosodium glutamate, Hypothalamus, Obesity, Dopamine

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          Abstract

          Monosodium glutamate (MSG) administration to neonatal mice results in destruction of the arcuate nucleus (AN) of the hypothalamus and numerous behavioral, endocrine and neurochemical sequelae. The present study assessed high-affinity neurotransmitter uptake into hypothalamic synaptosomes isolated from adult mice which were treated on postnatal day 4 with either MSG (4 mg/g) or saline. MSG treatment produced a significant reduction in synaptosomal uptake of dopamine (DA), choline (Ch) and GABA when expressed in terms of hypothalamic wet weight. However, MSG treatment resulted in a significant loss (70%) of synaptosomal protein and consequent increases in synaptosomal uptake of these neurochemicals when expressed per unit of synaptosomal protein. The results indicate that MSG treatment produced an overall reduction in net hypothalamic uptake, with surviving neuronal elements exhibiting an increased uptake which may reflect compensatory changes in these nerve terminals. MSG may thus disrupt pituitary and intrahypothalamic functions via its effects on neuronal systems of the AN.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1982
          1982
          26 March 2008
          : 34
          : 4
          : 292-296
          Affiliations
          Division of Toxicology, Department of Environmental Health Sciences, The Johns Hopkins University, Baltimore, Md., USA
          Article
          123315 Neuroendocrinology 1982;34:292–296
          10.1159/000123315
          6122172
          © 1982 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 5
          Categories
          Original Paper

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