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      Controlling nuclear receptors: the circular logic of cofactor cycles

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      Nature Reviews Molecular Cell Biology
      Springer Nature

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          Abstract

          Nuclear receptors regulate many biologically important processes in development and homeostasis by their bimodal function as repressors and activators of gene transcription. A finely tuned modulation of the transcriptional activities of nuclear receptors is crucial for determining highly specific and diversified programmes of gene expression. Recent studies have provided insights into the molecular mechanisms that are required to switch between repression and activation functions, the combinatorial roles of the multiple cofactor complexes that are required for mediating transcriptional regulation, and the central question of how several different signalling pathways can be integrated at the nuclear level to achieve specific profiles of gene expression.

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          Author and article information

          Journal
          Nature Reviews Molecular Cell Biology
          Nat Rev Mol Cell Biol
          Springer Nature
          1471-0072
          1471-0080
          July 2005
          July 2005
          : 6
          : 7
          : 542-554
          Article
          10.1038/nrm1680
          15957004
          7e0a5885-43a6-4cd3-8894-8c9d643a3a87
          © 2005
          History

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