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      Novel bioactive root canal sealer to inhibit endodontic multispecies biofilms with remineralizing calcium phosphate ions.

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          Abstract

          The objectives of this study were to: (1) develop a bioactive endodontic sealer via dimethylaminohexadecyl methacrylate (DMAHDM), 2-methacryloyloxyethyl phosphorylcholine (MPC) and nanoparticles of amorphous calcium phosphate (NACP) for the first time; and (2) evaluate inhibition of early-stage and mature multispecies endodontic biofilm, bond strength to root canal dentine, and calcium (Ca) and phosphate (P) ion release.

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          Author and article information

          Journal
          J Dent
          Journal of dentistry
          Elsevier BV
          1879-176X
          0300-5712
          May 2017
          : 60
          Affiliations
          [1 ] VIP Integrated Department, Stomatological Hospital of Jilin University, Changchun, China; Department of Endodontics, Periodontics and Prosthodontics, University of Maryland School of Dentistry, Baltimore, MD 21201, USA.
          [2 ] Department of Endodontics, Periodontics and Prosthodontics, University of Maryland School of Dentistry, Baltimore, MD 21201, USA; Department of Orthodontics, School of Stomatology, Capital Medical University, Beijing, China.
          [3 ] Department of Oral Implantology, School and Hospital of Stomatology, Jilin University, Changchun, China.
          [4 ] L.D. Caulk Division, Dentsply Sirona Restorative, Milford, DE 19963, USA.
          [5 ] Department of Endodontics, Periodontics and Prosthodontics, University of Maryland School of Dentistry, Baltimore, MD 21201, USA; Department of Orthodontics, School of Stomatology, Capital Medical University, Beijing, China. Electronic address: tuzizhangke@163.com.
          [6 ] Department of Oral Implantology, School and Hospital of Stomatology, Jilin University, Changchun, China. Electronic address: zhouym62@126.com.
          [7 ] Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, Department of Implant Dentistry, School of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi, China. Electronic address: changxf@mail.xjtu.edu.cn.
          [8 ] Department of Endodontics, Periodontics and Prosthodontics, University of Maryland School of Dentistry, Baltimore, MD 21201, USA; Center for Stem Cell Biology & Regenerative Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA; Department of Mechanical Engineering, University of Maryland Baltimore County, Baltimore County, MD 21250, USA.
          Article
          S0300-5712(17)30039-8
          10.1016/j.jdent.2017.02.011
          28223198
          7e1a6354-c6c5-4ca0-9e15-e0de90edcd5b
          History

          Antibacterial,Bond strength,Calcium phosphate remineralization,Endodontic biofilms,Protein repellent,Root canal sealer

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