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      Regulation of the latent-lytic switch in Epstein-Barr virus.

      Seminars in Cancer Biology

      Animals, DNA Methylation, Epstein-Barr Virus Infections, virology, Gene Expression Regulation, Viral, Genome, Viral, Herpesvirus 4, Human, physiology, Humans, Neoplasms, therapy, Oncolytic Virotherapy, Oncolytic Viruses, Virus Activation, Virus Latency, Virus Replication

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          Abstract

          Epstein-Barr virus (EBV) infection contributes to the development of several different types of human malignancy, including Burkitt lymphoma, Hodgkin lymphoma, and nasopharyngeal carcinoma. As a herpesvirus, EBV can establish latent or lytic infection in cells. EBV-positive tumors are composed almost exclusively of cells with latent EBV infection. Strategies for inducing the lytic form of EBV infection in tumor cells are being investigated as a potential therapy for EBV-positive tumors. In this article, we review how cellular and viral proteins regulate the latent-lytic EBV switch in infected B cells and epithelial cells, and discuss how harnessing lytic viral reactivation might be used therapeutically. Copyright © 2014 Elsevier Ltd. All rights reserved.

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          Journal
          24457012
          4048781
          10.1016/j.semcancer.2014.01.002

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