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      Neurotrophic Effects of Fibroblast Growth Factors on Peptide-Containing Neurons in Culture from Postnatal Rat Hypothalamus

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          Basic fibroblast growth factor (bFGF) has been thought to act as a neurotrophic factor during early developmental stages in various brain regions, including the hypothalamus. In the present paper, we have studied the effect of bFGF on peptide-containing neurons cultured from the postnatal (1–3 days and 14 days after birth) rat hypothalamus. The addition of bFGF, or acid FGF (aFGF), to serum-free culture medium increased both survival and neurite growth of growth hormone-releasing factor (GRF)-containing neurons. The potency of bFGF was more than 10 times as great as that of aFGF. Insulinlike growth factor I (IGF-1) did not have any significant effect on the survival of GRF neurons. Further, neither IGF-1 nor aFGF modified the survival-promoting effect of bFGF on GRF neurons. bFGF promoted the survival of somatostatin- and vasoactive intestinal polypeptide-containing neurons, too.

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          Author and article information

          S. Karger AG
          07 April 2008
          : 55
          : 2
          : 193-198
          Departments of aPhysiology and bProtein Chemistry, Institute of Endocrinology, Gunma University, Maebashi, Japan
          126114 Neuroendocrinology 1992;55:193–198
          © 1992 S. Karger AG, Basel

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          Pages: 6
          Original Paper


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