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      The Influence of the Nervous System upon Adrenal Gland Weight and Assayable Pituitary MSH

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          Abstract

          A series of experiments were designed to test the assumption that neuro-regulatory mechanisms associated with pituitary ACTH and melanotropin (MSH) secretions are interdependent. Stress elevates both ACTH and MSH activity in mouse pituitaries. There are nervous influences on the secretion of both of these hormones. We have undertaken to stimulate or block various components of the nervous control of these 2 hormones in order to determine whether the 2 are controlled by the same mechanisms or separate ones. We have exposed mice to neurotransmitter blocking agents against serotonin, norepinephrine and epinephrine – parachlorophenylalanine (PCPA), alpha-methyltyrosine (MT), propranolol – both with and without stress. Unilateral adrenalectomy with and without hydrocortisone replacement therapy were investigated. We found that none of the neuro-active substances altered stress elevation of ACTH and MSH. Unilaterally adrenalectomized stressed animals treated with hydrocortisone showed elevated pituitary MSH levels but non increased ACTH release, as measured by size of the remaining adrenal. Adrenalectomy of animals without replacement therapy showed both elevated pituitary MSH and increased ACTH activity Since the ACTH and MSH activity behave independently in the last described experiments, we conclude that ACTH and MSH are independently controlled.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1978
          1978
          26 March 2008
          : 27
          : 5-6
          : 228-238
          Affiliations
          School of Life Sciences, University of Nebraska, Lincoln, Nebr.
          Article
          122815 Neuroendocrinology 1978;27:228–238
          10.1159/000122815
          153481
          7e3e7a3e-54d3-4d6f-8359-35c94a929430
          © 1978 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          : 28 November 1977
          : 04 June 1978
          Page count
          Pages: 11
          Categories
          Paper

          Endocrinology & Diabetes,Neurology,Nutrition & Dietetics,Sexual medicine,Internal medicine,Pharmacology & Pharmaceutical medicine
          Catecholamine-depleting agents,MSH,Serotonin-depleting agents,Stress,Nervous control of MSH,Nervous control of ACTH,ACTH

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