[1
]Gastrointestinal Unit, Centre for Genomics and Molecular Medicine, University of Edinburgh , Edinburgh EH4 6XU, UK
[2
]CNAG-CRG, Centro Nacional de Análisis Genómico, Centre for Genomic Regulation (CRG),
Barcelona Institute of Science and Technology (BIST) , Baldiri i Reixac 4, Barcelona 08028, Spain
[3
]Universitat Pompeu Fabra (UPF) , Barcelona 08002, Spain
[4
]Department of Child Life and Health, University of Edinburgh , Edinburgh EH9 1UW, UK
[5
]Genos Glycoscience Research Laboratory , Hondlova 2/11, Zagreb 10000, Croatia
[6
]Centre for Population Health Sciences, University of Edinburgh , Edinburgh EH8 9AG, UK
[7
]F.Widjaja Family Foundation Inflammatory Bowel and Immunobiology Research Institute,
Cedars-Sinai Medical Center , Los Angeles, California 90048, USA
[8
]Department of Medical and Surgical Sciences, Division of Gastroenterology University
Hospital Careggi , Largo Brambilla 3, Florence 50141, Italy
[9
]Department of Biochemistry and Molecular Biology, University of Zagreb Faculty of
Pharmacy and Biochemistry , A. Kovačića 1, Zagreb HR-10000, Croatia
[10
]IP Research Consulting SAS , 34 rue Carnot 93160 Noisy-le-grand, Paris, France
[11
]Center for Proteomics and Metabolomics, Leiden University Medical Center , Zone S3 Albinusdreef 2, Leiden 2333 ZA, The Netherlands
[12
]Division of BioAnalytical Chemistry, VU University Amsterdam , De Boelelaan 1083, room M-352, Amsterdam 1081 HV, The Netherlands
[13
]Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces , Potsdam-Golm Science Park, Potsdam D-14424, Germany
[14
]Ludger Ltd, Culham Science Centre , Oxford OX14 3EB, UK
[15
]Paediatric Gastroenterology Unit, AOU Meyer, Viale Pieraccini , Viale Pieraccini 24, Florence 50139, Italy
[16
]Department of Medical Sciences, Division of Gastroenterology, IRCCS-CSS Hospital , Viale Cappuccini, 1, S. Giovanni Rotondo, Rotondo, Italy
[17
]Division of Gastroenterology, S. Camillo Hospital , Via Portuense 332, Rome I-00149, Italy
[18
]Gastrointestinal Unit, University of Padua , Hospital Via Giustiniani 2, Padua 35128, Italy
[19
]IBD Unit, Humanitas Research Institute, Rozzano , Via Manzoni 56, Milan 20089, Italy
[20
]Department of Gastroenterology, Western General Hospital , Edinburgh EH4 6XU, UK
[21
]Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University
of Edinburgh and Medical Research Council Human Genetics Unit , Edinburgh EH4 6XU, UK
[22
]Wellcome Trust Clinical Research Facility, University of Edinburgh, Western General
Hospital , Edinburgh EH4 6XU, UK
[23
]Institute of Cytology and Genetics SB RAS , Novosibirsk 630090, Russia
[24
]Novosibirsk State University , Novosibirsk 630090, Russia
[25
]Maastricht University Medical Centre (MUMC) , P. Debyelaan 25, Maastricht 6229 HX, The Netherlands
[26
]Akershus University Hospital, Department of Gastroenterology , Sykehusveien 25, Lørenskog 1478, Akershus, Norway
[27
]Oslo University Hospital, Department of Gastroenterology , Bygg 6, 3 etg. Kirkeveien 166, Oslo N-0424, Norway
[28
]Linköping University Hospital, Department of Surgery , Linköping 581 83, Sweden
[29
]Department of Gastroenterology and Hepatology, UHL, County Council of Östergötland , Linköping 581 85, Sweden
[30
]Örebro University, Department of Gastroenterology, Faculty of Medicine and Health,
Långhuset , Fakultetsgatan 1, Örebro 702 81, Sweden
[31
]University of Zaragoza, Gastroenterology , Calle de Pedro Cerbuna, 12, Zaragoza 50009, Spain
[32
]BioCruces Health Research Institute, Cruces Plaza , Barakaldo, Bilbao 48903, Spain
[33
]Department of Biosciences and Nutrition, Karolinska Institutet , Stockholm SE-171 77, Sweden
[34
]Olink Proteomics, Uppsala Science Park , Hammarskjölds väg 52A, Uppsala 752 37, Sweden
[35
]Diagenode, Liege Science Park , Rue du Bois Saint-Jean 3, Liège 4102, Belgium
[36
]Genetic Analysis, Storo , Nycoveien 2, Oslo 0485, Norway
License:
This work is licensed under a Creative Commons Attribution 4.0 International License.
The images or other third party material in this article are included in the article's
Creative Commons license, unless indicated otherwise in the credit line; if the material
is not included under the Creative Commons license, users will need to obtain permission
from the license holder to reproduce the material. To view a copy of this license,
visit
http://creativecommons.org/licenses/by/4.0/
Epigenetic perturbations may be an important factor in diseases where both genes and
environment play a role. Here, Ventham and colleagues show that DNA methylation changes
in inflammatory bowel disease are related to the underlying genotype, and are associated
with cell-specific changes to gene expression.
