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      Structures of acetylated oleanane-type triterpene saponins, rarasaponins IV, V, and VI, and anti-hyperlipidemic constituents from the pericarps of Sapindus rarak.

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          Abstract

          The methanolic extract and its saponin fraction (methanol-eluted fraction) of the pericarps of Sapindus rarak DC. were found to suppress plasma triglyceride elevation in olive oil-treated mice. From the active fraction, three new acylated oleanane-type triterpene saponins, rarasaponins IV (1), V (2), and VI (3), were isolated. The structures of 1-3 were elucidated on the basis of chemical and spectroscopic evidence. The principle saponin constituents, hederagenin 3-O-alpha-L-arabinopyranosyl-(1-->3)-alpha-L-rhamnopyranosyl-(1-->2)-alpha-L-arabinopyranoside (4) and hederagenin 3-O-(3,4-di-O-acetyl-alpha-L-arabinopyranosyl)-(1-->3)-alpha-L-rhamnopyranosyl-(1-->2)-alpha-L-arabinopyranoside (5), showed inhibitory effects on plasma triglyceride elevation at a dose of 200 mg/kg, per os.

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          Author and article information

          Journal
          Chem. Pharm. Bull.
          Chemical & pharmaceutical bulletin
          0009-2363
          0009-2363
          Feb 2009
          : 57
          : 2
          Affiliations
          [1 ] Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Japan.
          Article
          JST.JSTAGE/cpb/57.198
          10.1248/cpb.57.198
          19182412
          7e58f634-c7e9-4cb4-98a9-1cf7fcee28d3
          History

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