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      Global prevalence of mental health issues among the general population during the coronavirus disease-2019 pandemic: a systematic review and meta-analysis

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          Abstract

          To provide a contemporary global prevalence of mental health issues among the general population amid the coronavirus disease-2019 (COVID-19) pandemic. We searched electronic databases, preprint databases, grey literature, and unpublished studies from January 1, 2020, to June 16, 2020 (updated on July 11, 2020), with no language restrictions. Observational studies using validated measurement tools and reporting data on mental health issues among the general population were screened to identify all relevant studies. We have included information from 32 different countries and 398,771 participants. The pooled prevalence of mental health issues amid the COVID-19 pandemic varied widely across countries and regions and was higher than previous reports before the COVID-19 outbreak began. The global prevalence estimate was 28.0% for depression; 26.9% for anxiety; 24.1% for post-traumatic stress symptoms; 36.5% for stress; 50.0% for psychological distress; and 27.6% for sleep problems. Data are limited for other aspects of mental health issues. Our findings highlight the disparities between countries in terms of the poverty impacts of COVID-19, preparedness of countries to respond, and economic vulnerabilities that impact the prevalence of mental health problems. Research on the social and economic burden is needed to better manage mental health problems during and after epidemics or pandemics. Systematic review registration: PROSPERO CRD 42020177120.

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          Bias in meta-analysis detected by a simple, graphical test

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            Quantifying heterogeneity in a meta-analysis.

            The extent of heterogeneity in a meta-analysis partly determines the difficulty in drawing overall conclusions. This extent may be measured by estimating a between-study variance, but interpretation is then specific to a particular treatment effect metric. A test for the existence of heterogeneity exists, but depends on the number of studies in the meta-analysis. We develop measures of the impact of heterogeneity on a meta-analysis, from mathematical criteria, that are independent of the number of studies and the treatment effect metric. We derive and propose three suitable statistics: H is the square root of the chi2 heterogeneity statistic divided by its degrees of freedom; R is the ratio of the standard error of the underlying mean from a random effects meta-analysis to the standard error of a fixed effect meta-analytic estimate, and I2 is a transformation of (H) that describes the proportion of total variation in study estimates that is due to heterogeneity. We discuss interpretation, interval estimates and other properties of these measures and examine them in five example data sets showing different amounts of heterogeneity. We conclude that H and I2, which can usually be calculated for published meta-analyses, are particularly useful summaries of the impact of heterogeneity. One or both should be presented in published meta-analyses in preference to the test for heterogeneity. Copyright 2002 John Wiley & Sons, Ltd.
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              The psychological impact of quarantine and how to reduce it: rapid review of the evidence

              Summary The December, 2019 coronavirus disease outbreak has seen many countries ask people who have potentially come into contact with the infection to isolate themselves at home or in a dedicated quarantine facility. Decisions on how to apply quarantine should be based on the best available evidence. We did a Review of the psychological impact of quarantine using three electronic databases. Of 3166 papers found, 24 are included in this Review. Most reviewed studies reported negative psychological effects including post-traumatic stress symptoms, confusion, and anger. Stressors included longer quarantine duration, infection fears, frustration, boredom, inadequate supplies, inadequate information, financial loss, and stigma. Some researchers have suggested long-lasting effects. In situations where quarantine is deemed necessary, officials should quarantine individuals for no longer than required, provide clear rationale for quarantine and information about protocols, and ensure sufficient supplies are provided. Appeals to altruism by reminding the public about the benefits of quarantine to wider society can be favourable.
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                Author and article information

                Contributors
                surapon.nochaiwong@gmail.com
                Journal
                Sci Rep
                Sci Rep
                Scientific Reports
                Nature Publishing Group UK (London )
                2045-2322
                13 May 2021
                13 May 2021
                2021
                : 11
                : 10173
                Affiliations
                [1 ]GRID grid.7132.7, ISNI 0000 0000 9039 7662, Department of Pharmaceutical Care, Faculty of Pharmacy, , Chiang Mai University, ; Chiang Mai, 50200 Thailand
                [2 ]GRID grid.7132.7, ISNI 0000 0000 9039 7662, Pharmacoepidemiology and Statistics Research Center (PESRC), Faculty of Pharmacy, , Chiang Mai University, ; Chiang Mai, 50200 Thailand
                [3 ]GRID grid.412687.e, ISNI 0000 0000 9606 5108, Ottawa Hospital Research Institute, , Ottawa Hospital, ; Ottawa, ON K1H 8L6 Canada
                [4 ]GRID grid.418647.8, ISNI 0000 0000 8849 1617, Institute of Clinical and Evaluative Sciences, , ICES uOttawa, ; Ottawa, ON K1Y 4E9 Canada
                [5 ]GRID grid.28046.38, ISNI 0000 0001 2182 2255, School of Epidemiology and Public Health, Faculty of Medicine, , University of Ottawa, ; Ottawa, ON K1G 5Z3 Canada
                [6 ]GRID grid.7132.7, ISNI 0000 0000 9039 7662, Department of Psychiatry, Faculty of Medicine, , Chiang Mai University, ; Chiang Mai, 50200 Thailand
                Author information
                http://orcid.org/0000-0003-1100-7171
                http://orcid.org/0000-0001-7927-1425
                http://orcid.org/0000-0003-4738-8447
                http://orcid.org/0000-0001-5662-8647
                http://orcid.org/0000-0003-3628-0596
                http://orcid.org/0000-0003-4184-0308
                http://orcid.org/0000-0001-8365-2474
                http://orcid.org/0000-0002-9062-3468
                Article
                89700
                10.1038/s41598-021-89700-8
                8119461
                33986414
                7e7f2ec8-f626-4e41-bb00-e95cc922b39e
                © The Author(s) 2021

                Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

                History
                : 11 January 2021
                : 29 April 2021
                Funding
                Funded by: FundRef 501100002842, Chiang Mai University (CMU);
                Categories
                Article
                Custom metadata
                © The Author(s) 2021

                Uncategorized
                post-traumatic stress disorder,depression,anxiety
                Uncategorized
                post-traumatic stress disorder, depression, anxiety

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