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      LUCLARICIN, A NEW LIGNAN FROM PHYLLANTHUS ACUMINATUS

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          Abstract

          The secondary metabolites of the aerial parts of Phyllanthus acuminatus Vahl (Phyllanthaceae) and the biological activity of one of them were characterized in this study. This chemical investigation led to isolation of two lignans, luclaricin (1), a new arylnaphtalene-typelignan, and justicidin B (2). The structures of isolated compounds were determined based on 1D and 2D-NMR, HRESIMS and IR. The cytotoxic activity of justicidin B was assessed against tumor cell lines (MCF-7, U251, NCI-ADR/RES, NCI-H460, OVCAR-3, HT29 and K562) and a non-tumor cell line (HaCat) using sulforhodamine B assay. Justicidin B showed strong cytotoxic activity against the tumor cell lines HT29, K562 and U251 with GI50 values of 2.28, 3.29 and 5.76 mol L-1, respectively.

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          Contributors
          Role: ND
          Role: ND
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          Journal
          qn
          Química Nova
          Quím. Nova
          Sociedade Brasileira de Química (São Paulo, SP, Brazil )
          0100-4042
          1678-7064
          August 2018
          : 41
          : 8
          : 880-883
          Affiliations
          [2] Campos dos Goytacazes Rio de Janeiro orgnameUniversidade Estadual do Norte Fluminense orgdiv1Centro de Ciência e Tecnologia Brazil
          [4] Campinas São Paulo orgnameUniversidade Estadual de Campinas orgdiv1Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrícolas orgdiv2Divisão de Farmacologia e Toxicologia Brazil
          [3] Seropédica Rio de Janeiro orgnameUniversidade Federal Rural do Rio de Janeiro orgdiv1Instituto de Ciências Exatas orgdiv2Departamento de Química Brazil
          [1] João Pessoa orgnameUniversidade Federal da Paraíba orgdiv1Centro de Ciências da Saúde Brazil
          Article
          S0100-40422018000800880
          10.21577/0100-4042.20170266
          7e84db9c-f5bf-4ac3-ad34-068133a2e222

          This work is licensed under a Creative Commons Attribution 4.0 International License.

          History
          : 12 July 2018
          : 18 March 2018
          Page count
          Figures: 0, Tables: 0, Equations: 0, References: 15, Pages: 4
          Product

          SciELO Brazil


          lignans,Phyllanthus,cytotoxicity,glioma cells
          lignans, Phyllanthus, cytotoxicity, glioma cells

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