1
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: not found
      • Article: not found

      Somatosensory cortical barrel dendritic abnormalities in a mouse model of the fragile X mental retardation syndrome

      , ,
      Brain Research
      Elsevier BV

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The Fragile X mental retardation syndrome is the largest source of inherited mental retardation. The syndrome usually results from the transcriptional silencing of the fragile X mental retardation gene (FMR1). To date the most prominent reported neuronal abnormalities for the fragile X mental retardation syndrome include a higher density of long thin spines similar to those found in sensory deprived and developing tissue, suggesting a possible deficit in pruning of immature spines. Dendrites on spiny stellate cells in the inner 1/3 of the barrel wall in layer IV of the rodent somatosensory cortex have been shown to exhibit developmental pruning similar to that affecting spines. To determine if FMRP plays a role in dendritic development, these neurons were examined in two strains of adult FMRP knockout (FraX) mice. FraX mice in both strains exhibited a greater amount of septa-oriented dendritic material, a morphology consistent with pre-pruning status early in development. This observation suggests that FMRP could be necessary for normal developmentally regulated dendritic pruning.

          Related collections

          Author and article information

          Journal
          Brain Research
          Brain Research
          Elsevier BV
          00068993
          May 2003
          May 2003
          : 971
          : 1
          : 83-89
          Article
          10.1016/S0006-8993(03)02363-1
          12691840
          7e85a7c0-a5f9-46c2-a159-f31f2a525058
          © 2003

          https://www.elsevier.com/tdm/userlicense/1.0/

          History

          Comments

          Comment on this article