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Editorial: Neuropeptides and Behavior: From Motivation to Psychopathology

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      THE INFLUENCE OF THE POSTERIOR AND INTERMEDIATE LOBE OF THE PITUITARY AND PITUITARY PEPTIDES ON THE MAINTENANCE OF A CONDITIONED AVOIDANCE RESPONSE IN RATS.

       D. De Wled (1965)
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        Neuropeptides in psychiatric diseases: an overview with a particular focus on depression and anxiety disorders.

        This paper aimed at reviewing the involvement of neuropeptides in various psychiatric diseases, particularly in depression, and anxiety disorders. General features of neuropeptides are first described, including the history of their discovery, their definition, classification, biosynthesis, transport, release, inactivation, as well as their interaction with specific neuronal receptors. The differences with classical neurotransmitters are mentioned, as well as the different patterns of co-transmission. Finally, different mechanisms, both at the cellular and at the systemic level, are proposed that may explain the involvement of these molecules in various psychiatric diseases. Indeed, at the cellular level, a neuropeptide can be involved in a psychiatric disease, either because it is co-localized with a classical neurotransmitter involved in a disease, or because the neuropeptide-containing neuron projects on a target neuron involved in the disease. At the systemic level, a neuropeptide can play a direct role in the expression of a symptom of the disease. This is illustrated by different examples.
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          Author and article information

          Affiliations
          1Departamento de Psicobiologia, Escola Paulista de Medicina, Universidade Federal de São Paulo , São Paulo, Brazil
          2Department of Molecular and Integrative Physiology, University of Michigan , Ann Arbor, MI, United States
          Author notes

          Edited and Reviewed by: Hubert Vaudry, University of Rouen, France

          *Correspondence: Deborah Suchecki, deborah.suchecki@ 123456gmail.com

          Specialty section: This article was submitted to Neuroendocrine Science, a section of the journal Frontiers in Endocrinology

          Contributors
          URI : http://frontiersin.org/people/u/5754
          Journal
          Front Endocrinol (Lausanne)
          Front Endocrinol (Lausanne)
          Front. Endocrinol.
          Frontiers in Endocrinology
          Frontiers Media S.A.
          1664-2392
          25 August 2017
          2017
          : 8
          5574876 10.3389/fendo.2017.00210
          Copyright © 2017 Suchecki and Elias.

          This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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          Figures: 0, Tables: 0, Equations: 0, References: 2, Pages: 3, Words: 1545
          Categories
          Endocrinology
          Editorial

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