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      Continuous LVAD monitoring reveals high suction rates in clinically stable outpatients

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          Abstract

          Suction of the left ventricle can lead to potentially life‐threatening events in left ventricular assist device (LVAD) patients. With the resolution of currently available clinical LVAD monitoring healthcare professionals are unable to evaluate patients’ suction occurrences in detail. This study investigates occurrences and durations of suction events and their associations with tachycardia in stable outpatients. Continuous high‐resolution LVAD data from HVAD patients were analyzed in the early outpatient period for 15 days. A validated suction detection from LVAD signals was used. Suction events were evaluated as suction rates, bursts of consecutive suction beats, and clusters of suction beats. The occurrence of tachycardia was analyzed before, during, and after suction clusters. Furthermore, blood work, implant strategy, LVAD speed setting, inflow cannula position, left ventricular diameters, and adverse events were evaluated in these patients. LVAD data of 10 patients was analyzed starting at 78 ± 22 postoperative days. Individuals’ highest suction rates per hour resulted in a median of 11% (range 3%‐61%). Bursts categorized as consecutive suction beats with n = 2, n = 3‐5, n = 6‐15, and n > 15 beats were homogenously distributed with 10.3 ± 0.8% among all suction beats. Larger suction bursts were followed by shorter suction‐free periods. Tachycardia during suction occurred in 12% of all suction clusters. Significant differences in clinical parameters between individuals with high and low suction rates were only observed in left ventricular end‐diastolic and end‐systolic diameters ( P < .02). Continuous high‐resolution LVAD monitoring sheds light on outpatient suction occurrences. Interindividual and intraindividual characteristics of longitudinal suction rates were observed. Longer suction clusters have higher probabilities of tachycardia within the cluster and more severe types of suction waveforms. This work shows the necessity of improved LVAD monitoring and the implementation of an LVAD speed control to reduce suction rates and their concomitant burden on the cardiovascular system.

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          The Society of Thoracic Surgeons Intermacs database annual report: Evolving indications, outcomes, and scientific partnerships

          The Interagency Registry for Mechanically Assisted Circulatory Support (Intermacs), a joint effort among the National Heart, Lung, and Blood Institute, the Food and Drug Administration, the Centers for Medicare and Medicaid Services, and others, was established in 2005 at the University of Alabama at Birmingham. The registry examined clinical outcomes and quality-of-life metrics of patients who received an Food and Drug Administration-approved durable mechanical circulatory support (MCS) device to treat advanced heart failure. On January 1, 2018, the Intermacs Database became part of The Society of Thoracic Surgeons National Database, providing additional resources for quality assessment and improvement and scientific advancement.
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            Echocardiography in the Management of Patients with Left Ventricular Assist Devices: Recommendations from the American Society of Echocardiography

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              Design Rationale and Preclinical Evaluation of the HeartMate 3 Left Ventricular Assist System for Hemocompatibility.

              The HeartMate 3 (HM3) left ventricular assist device (LVAD) is designed to support advanced heart failure patients. This centrifugal flow pump has a magnetically levitated rotor, artificial pulse, textured blood-contacting surfaces, optimized fluid dynamics, large blood-flow gaps, and low shear stress. Preclinical tests were conducted to assess hemocompatibility. A computational fluid dynamics (CFD) model guided design for low shear stress and sufficient washing. Hemolysis testing was conducted on six pumps. Plasma-free hemoglobin (PfHb) and modified index of hemolysis (MIH) were compared with HeartMate II (HMII). CFD showed secondary flow path residence times between 27 and 798 min, comparable with main flow residence times between 118 and 587 min; HM3 vs. HMII shear stress exposure above 150 Pa was 3.3 vs. 11 mm within the pump volume and 134 vs. 604 mm on surfaces. In in vitro hemolysis tests at 2, 5, and 10 L/min, average pfHb 6 hours after test initiation was 58, 74, and 157 mg/dl, compared with 112, 123, and 353 mg/dl for HMII. The HM3/HMII ratio of average MIH at 2, 5, and 10 L/min was 0.29, 0.36, and 0.22. Eight 60 day bovine implants were tested with average flow rates from 5.6 to 6.4 L/min with no device failures, thrombosis, or hemolysis. Results support advancing HM3 to clinical trials.
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                Author and article information

                Contributors
                francesco.moscato@meduniwien.ac.at
                Journal
                Artif Organs
                Artif Organs
                10.1111/(ISSN)1525-1594
                AOR
                Artificial Organs
                John Wiley and Sons Inc. (Hoboken )
                0160-564X
                1525-1594
                01 March 2020
                July 2020
                : 44
                : 7 ( doiID: 10.1111/aor.v44.7 )
                : E251-E262
                Affiliations
                [ 1 ] Center for Medical Physics and Biomedical Engineering Medical University of Vienna Vienna Austria
                [ 2 ] Ludwig Boltzmann Institute Cardiovascular Research Vienna Austria
                [ 3 ] Division of Cardiac Surgery Department of Surgery Medical University of Vienna Vienna Austria
                Author notes
                [*] [* ] Correspondence

                Francesco Moscato, Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Waehringer Guertel 18‐20 AKH‐4L, Vienna 1090, Austria.

                Email: francesco.moscato@ 123456meduniwien.ac.at

                Author information
                https://orcid.org/0000-0003-1583-5783
                https://orcid.org/0000-0003-4354-4860
                https://orcid.org/0000-0003-0279-6615
                Article
                AOR13638
                10.1111/aor.13638
                7318142
                31945201
                7ec655e9-7e25-4a49-a6d6-93d08b65b82b
                © 2020 The Authors. Artificial Organs published by International Center for Artificial Organ and Transplantation (ICAOT) and Wiley Periodicals, Inc.

                This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

                History
                : 16 August 2019
                : 08 January 2020
                : 08 January 2020
                Page count
                Figures: 7, Tables: 3, Pages: 12, Words: 13706
                Funding
                Funded by: Austrian Science Fund , open-funder-registry 10.13039/501100002428;
                Award ID: KLI357
                Categories
                Main Text Article
                Electronic‐only Articles
                Main Text Articles
                Custom metadata
                2.0
                July 2020
                Converter:WILEY_ML3GV2_TO_JATSPMC version:5.8.4 mode:remove_FC converted:26.06.2020

                Transplantation
                left ventricular assist device,mechanical circulatory support,outpatient monitoring,overpumping,suction,tachycardia

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