Automated annotation of mobile antibiotic resistance in Gram-negative bacteria: the Multiple Antibiotic Resistance Annotator (MARA) and database.

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Abstract

Multiresistance in Gram-negative bacteria is often due to acquisition of several different antibiotic resistance genes, each associated with a different mobile genetic element, that tend to cluster together in complex conglomerations. Accurate, consistent annotation of resistance genes, the boundaries and fragments of mobile elements, and signatures of insertion, such as DR, facilitates comparative analysis of complex multiresistance regions and plasmids to better understand their evolution and how resistance genes spread.

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Author and article information

Journal

Journal ID (iso-abbrev): J. Antimicrob. Chemother.

Title: The Journal of antimicrobial chemotherapy

Publisher: Oxford University Press (OUP)

ISSN (Electronic): 1460-2091

ISSN (Print): 0305-7453

Publication date (Electronic): Apr 01 2018

Volume: 73

Issue: 4

Affiliations

[1 ] Centre for Infectious Diseases and Microbiology, The Westmead Institute for Medical Research, The University of Sydney, Westmead Hospital, Sydney, Australia.

[2 ] Centre for Health Informatics, Australian Institute of Health Innovation, Macquarie University, Sydney, Australia.

[3 ] Spokade Pty Ltd, Sydney, Australia.

Article

Publisher Item ID: 4823430

DOI: 10.1093/jac/dkx513

PubMed ID: 29373760

SO-VID: 7ecf14ee-7c07-47ca-a174-fbd70203cf7c

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