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      • Abstract: found
      • Article: found
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      Cyclosporine in the Management of Impetigo Herpetiformis: A Case Report and Review of the Literature

      case-report

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          Abstract

          A 27-year-old female, gravida 1, para 0, in week 22 of pregnancy, presented with an eruption consisting of annular erythematosquamous plaques with an active polycyclic elevated border comprised of superficial micropustules. Clinical and histological features were typical of impetigo herpetiformis (IH). Systemic steroids resulted in an unstable condition, with no resolution of lesions. Resistance to the above therapeutic scheme served as a stimulus to discuss the use of cyclosporine as a therapeutic option in this condition. Reviewing the limited literature, cyclosporine seems to serve not as a monotherapy in the management of IH but as an additional medication, in order to achieve a stable course of the disease and avoid high doses of systemic steroids.

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          Pregnancy dermatoses: diagnosis, management, and controversies.

          Maria Roth (2011)
          Some aspects regarding the etiology and the nosologic classification of various pregnancy dermatoses are highly controversial. While some authors highlight the existence of premises allowing several skin disorders to be re-grouped within broader disease concepts, others underline the absence of clear, undisputed etiopathogenetic data that could support such classifications. This review exhaustively analyzes the various pregnancy dermatoses (pemphigoid gestationis, intrahepatic cholestasis of pregnancy, impetigo herpetiformis, polymorphic eruption of pregnancy, and the papular dermatoses of pregnancy [prurigo of pregnancy, pruritic folliculitis of pregnancy, and the new classification, atopic eruption of pregnancy]) in an attempt to shed light over this confusing and disputed domain, while subsequently offering an algorithmic approach to their diagnosis and management. While for pemphigus gestationis, intrahepatic cholestasis of pregnancy, and impetigo herpetiformis, specific diagnostic tests such as histopathology, immunofluorescence, or laboratory investigations will confirm the diagnosis, the identification of the other types of pregnancy dermatoses is based only on clinical criteria. In this context, the review argues for the inclusion of the whole group represented by the papular dermatoses of pregnancy within the broad spectrum of polymorphic eruption of pregnancy, separating each of these entities by focusing on their onset: early-onset polymorphic eruption of pregnancy (comprising prurigo of pregnancy, pruritic folliculitis of pregnancy, and atopic eruption of pregnancy) and late-onset polymorphic eruption of pregnancy. In light of the same practical approach guiding it, the review provides updated treatment strategies for each of these conditions.
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            Impetigo herpetiformis unresponsive to therapy in a pregnant adolescent.

            Ilhan Arslanpence, F.Suat Dede, Mehmet Gokcu … (2003)
            Impetigo herpetiformis is a rare pustular disorder affecting mainly pregnant women. We report a 16-yr-old adolescent primigravida, who presented with impetigo herpetiformis at 27 weeks gestation. She had a pustular erythroderma covering her entire body, except face, scalp, and palmoplantar regions, with severe pruritus and pain. After unsuccessful attempts of treatment with systemic corticosteroids, intravenous fluids, and antibiotics, treatment was switched to cyclosporine, but no therapeutic effect could be achieved. Because of the deteriorating condition of the patient, an early delivery decision was made. Her symptoms resolved after delivery, and at day 20 postpartum her skin lesions were completely resolved.
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              Generalized pustular psoriasis of pregnancy treated with infliximab.

              D. N. Sheth, F. Teixeira, K Acland … (2009)
              Article 0 comments Cited 10 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (publisher-id): CDE
                Journal ID (pmc): CDE
                Journal ID (doi): 10.1159/issn.1662-6567
                Title: Case Reports in Dermatology
                Publisher: S. Karger AG
                ISSN (Electronic): 1662-6567
                Publication date Subscription-year: 2013
                Publication date Collection: January – April 2013
                Publication date (Electronic): 23 March 2013
                Volume: 5
                Issue: 1
                Pages: 99-104
                Affiliations
                a2nd Department of Dermatology and Venereology, and b1st Department of Obstetrics and Gynecology, Aristotle University School of Medicine, Papageorgiou Hospital, Thessaloniki, Greece
                Author notes
                *Aikaterini Kyriakou, 10, Ilia Pilidi Street, GR-55236 Thessaloniki (Greece), E-Mail docmouli@gmail.com
                Article
                Publisher ID: 350564 Pmcid ID: PMC3635965 Other ID: Case Rep Dermatol 2013;5:99-104
                DOI: 10.1159/000350564
                PMC ID: PMC3635965
                PubMed ID: 23626548
                SO-VID: 7edeb227-abdd-495c-9607-6ff8bc41eac1
                Copyright © © 2013 S. Karger AG, Basel
                License:

                Open Access License: This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) ( http://www.karger.com/OA-license), applicable to the online version of the article only. Distribution permitted for non-commercial purposes only. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

                History
                Page count
                Figures: 3, Tables: 1, Pages: 6
                Categories
                Subject: Published: March 2013

                ScienceOpen disciplines: Oncology & Radiotherapy,Pathology,Surgery,Dermatology,Pharmacology & Pharmaceutical medicine
                Keywords: Cyclosporine,Psoriasis,Impetigo,Herpetiformis,Pustular, psoriasis
                Data availability:
                ScienceOpen disciplines: Oncology & Radiotherapy, Pathology, Surgery, Dermatology, Pharmacology & Pharmaceutical medicine
                Keywords: Cyclosporine, Psoriasis, Impetigo, Herpetiformis, Pustular, psoriasis

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