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      Immunoallergic Granulomatous Interstitial Nephritis following Treatment with Omeprazole

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          A 69-year-old male who had a long history of ocular myasthenia was treated with omeprazole for 3 months. Progressive renal insufficiency was discovered fortuitously. There were no clinical or laboratory manifestations of immunoallergy. Renal biopsy revealed severe granulomatous interstitial nephritis, tubular injury and fibrosis. Histology of a liver nodule disclosed hepatic granulomatous involvement. Withdrawal of omeprazole and a short course of corticosteroids were followed by improvement but not normalization of renal function. This is the eighth report of omeprazole-induced interstitial nephritis. In the present case as in 2 others in the literature, the patients had been followed up for an autoimmune disease previously, which suggests that in patients with such a background, patients should be examined regularly for renal functional impairment during treatment with omeprazole.

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          Author and article information

          Am J Nephrol
          American Journal of Nephrology
          S. Karger AG
          June 1998
          06 May 1998
          : 18
          : 3
          : 243-246
          a Service de Néphrologie, Hôpital Intercommunal, Montreuil, and b Service de Néphrologie and INSERM U 430, Hôpital Broussais, Paris, France
          13345 Am J Nephrol 1998;18:243–246
          © 1998 S. Karger AG, Basel

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          Figures: 2, Tables: 2, References: 16, Pages: 4
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