Blog
About

0
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found

      Hypertension in Primary Immunoglobulin A Nephropathy (Berger’s Disease): Hemodynamic Alterations and Mechanisms

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Twenty-two patients with primary IgA nephropathy (Berger’s disease), 12 with normal and 10 with high blood pressure, were studied. The mean intra-arterial pressure was 88 ± 6 mm Hg in the normotensive group and 113 ± 10mm Hg in hypertensive patients; plasma renin activity was high in normotensives and normal in hypertensives. The glomerular filtration rate was 83 ± 23 and 73 ± 26 ml/m in 1.73m<sup>2</sup> in normotensive and hypertensive patients, respectively (p = n.s.). Blood volume was high in IgA nephropathy patients: 82 ± 12 ml/kg body weight in normotensives and 96 ± 7 ml/kg body weight in hypertensives. Mean arterial pressure was significantly correlated with blood volume (r = 0.541, p < 0.0l), but not with plasma renin activity and glomerular filtration rate. The cardiac index was high in both groups: 4.20 ± 0.88 liters/min/m<sup>2</sup> in normotensive and 3.95 ± 0.87 liters/min/m<sup>2</sup> in hypertensive patients. The total peripheral resistance index was significantly lower than normal in normotensives (1,659 ± 387 dyn/s/ cm<sup>-5</sup>m<sup>2</sup>) and significantly higher (2,419 ± 562 dyn/s/cm<sup>-5</sup>m<sup>2</sup>) in hypertensives. The cardiac index did not correlate with blood volume and mean arterial pressure; a positive correlation was found between mean arterial pressure and peripheral vascular resistance (r = 0.630, p < 0.01). No correlation was observed between blood volume and plasma renin activity. Our study indicates that hypertension in IgA nephropathy is primarily volume dependent, and that this increase in blood volume is not related to the deterioration of renal function. The role of the renin-angiotensin system in the maintenance of the hypertension is not well-defined. Hemodynamically, hypertension is characterized by high cardiac output and high total peripheral resistance.

          Related collections

          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1987
          1987
          05 December 2008
          : 45
          : 3
          : 219-223
          Affiliations
          aDivisione Clinicizzata di Nefrologia, e bServizio di Medicina Nucleare, Istituti Ospitalieri, Verona, Italia
          Article
          184121 Nephron 1987;45:219–223
          10.1159/000184121
          3553975
          © 1987 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 5
          Categories
          Original Paper

          Comments

          Comment on this article