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      Ibopamine in the Treatment of Mild Chronic Heart Failure in Elderly Patients

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          Abstract

          This double-blind, randomized, multicenter clinical study assessed the efficacy and safety of ibopamine 100 mg t.i.d. as monotherapy vs. placebo in 52 patients with mild chronic heart failure aged over 60 years during a 12-week treatment period. Ibopamine produced a statistically significant increase in exercise tolerance and reduction in fatigue during effort compared to placebo. A trend towards decreased requirement of concomitant diuretic therapy was noted in the ibopamine-treated group. Ibopamine was well tolerated throughout the study. This study indicated that ibopamine is an effective and safe agent as monotherapy in the treatment of mild chronic heart failure in elderly patients.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          978-3-8055-5309-4
          978-3-318-01566-9
          0008-6312
          1421-9751
          1990
          1990
          12 November 2008
          : 77
          : Suppl 5
          : 89-95
          Affiliations
          aProfessorial Department of Medical Pathology, University of Genova; bI.N.R.C.A., Department of Cardiology, Casatenovo, Como; cGeriatric Hospital ‘A. Doria’, Genoa; d’Department of Cardiology, General Hospital. Matera; eDepartment of Biostatistics, Zambon Group S.p.A., Bresso-Milano, Italy
          Article
          174702 Cardiology 1990;77:89–95
          10.1159/000174702
          2279258
          7f132444-ce2c-4e61-834f-f7969b3bf063
          © 1990 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          Page count
          Pages: 7
          Categories
          Ibopamine in the Management of Congestive Heart Failure

          General medicine,Neurology,Cardiovascular Medicine,Internal medicine,Nephrology
          Elderly,Chronic heart failure,Ibopamine

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