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      The immunology of fibrosis: innate and adaptive responses

      , , , , ,
      Trends in Immunology
      Elsevier BV

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          Abstract

          Fibrosis is an important health problem, and its pathogenetic principles are still largely unknown. It can develop either spontaneously, or, more frequently, as a consequence of various underlying diseases. Irrespective of the primary cause, however, fibrotic tissue is always infiltrated by mononuclear immune cells. In most instances the reason for the attraction of these cells to fibrotic tissue and their proliferation remains to be determined; however their cytokine profile shows clear-cut proinflammatory and profibrotic characteristics. In this review, we discuss the innate and adaptive immune reactions associated with the development of fibrosis and the molecular basis of the profibrotic mechanisms taking place in systemic sclerosis (scleroderma), arteriosclerosis and peri-silicone mammary implant fibrosis. Copyright 2009 Elsevier Ltd. All rights reserved.

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          Author and article information

          Journal
          Trends in Immunology
          Trends in Immunology
          Elsevier BV
          14714906
          March 2010
          March 2010
          : 31
          : 3
          : 110-119
          Article
          10.1016/j.it.2009.12.001
          3292796
          20106721
          7f1fbeb3-583b-494c-94b5-bac7fd2ba7dd
          © 2010

          https://www.elsevier.com/tdm/userlicense/1.0/

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