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      Characterization of Glycoconjugates in the Human Cameral Mucous Gel by Lectins

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          A cameral mucous gel (CMG) has been described in human eyes lining the anterior and posterior ocular chambers. We assay a battery of 11 lectins to characterize the accessible sugars of the presumed glycoproteins and glycosaminoglycans present in the gel. Results show a predominance of alpha-linked sugars over beta-linked ones. There is evidence for the prominence in the gel of α-N-acetyl- D-galactosamine and/or α- D-galactose, together with α-N-acetyl-glucosamine. The second most important sugars are β-N-acetyl- D-glucosamine and the dissacharide β- D-galactose-N-acetyl- D-galactosamine. β-N-acetyl-galactosamine could possibly be identified in third place. Neither fucose nor mannose are detected. These results point towards heparan and perlecan as possible components of the glycidic fraction of the gel, although a specific proteo-glycan adapted to the osmotic role of the CMG is not at all unlikely.

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          Author and article information

          Ophthalmic Res
          Ophthalmic Research
          S. Karger AG
          11 December 2009
          : 26
          : 5
          : 275-282
          aDepartment of Surgery (Ophthalmology), Faculty of Medicine, and bElectron Microscopy Section, Technical Services Department, University of Granada, cDepartment of Pathology, University Hospital of Granada, Spain
          267489 Ophthalmic Res 1994;26:275–282
          © 1994 S. Karger AG, Basel

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          Pages: 8
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