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      Characterization of Glycoconjugates in the Human Cameral Mucous Gel by Lectins

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          Abstract

          A cameral mucous gel (CMG) has been described in human eyes lining the anterior and posterior ocular chambers. We assay a battery of 11 lectins to characterize the accessible sugars of the presumed glycoproteins and glycosaminoglycans present in the gel. Results show a predominance of alpha-linked sugars over beta-linked ones. There is evidence for the prominence in the gel of α-N-acetyl- D-galactosamine and/or α- D-galactose, together with α-N-acetyl-glucosamine. The second most important sugars are β-N-acetyl- D-glucosamine and the dissacharide β- D-galactose-N-acetyl- D-galactosamine. β-N-acetyl-galactosamine could possibly be identified in third place. Neither fucose nor mannose are detected. These results point towards heparan and perlecan as possible components of the glycidic fraction of the gel, although a specific proteo-glycan adapted to the osmotic role of the CMG is not at all unlikely.

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          Author and article information

          Journal
          ORE
          Ophthalmic Res
          10.1159/issn.0030-3747
          Ophthalmic Research
          S. Karger AG
          0030-3747
          1423-0259
          1994
          1994
          11 December 2009
          : 26
          : 5
          : 275-282
          Affiliations
          aDepartment of Surgery (Ophthalmology), Faculty of Medicine, and bElectron Microscopy Section, Technical Services Department, University of Granada, cDepartment of Pathology, University Hospital of Granada, Spain
          Article
          267489 Ophthalmic Res 1994;26:275–282
          10.1159/000267489
          7877797
          © 1994 S. Karger AG, Basel

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          Page count
          Pages: 8
          Categories
          Original Paper

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