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      Effect of SSRI Antidepressants on Ejaculation : A Double-Blind, Randomized, Placebo-Controlled Study With Fluoxetine, Fluvoxamine, Paroxetine, and Sertraline

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          Paroxetine treatment of premature ejaculation: a double-blind, randomized, placebo-controlled study.

          Seventeen male outpatients with premature ejaculation were randomly assigned to treatment with paroxetine (N = 8) or placebo (N = 9). After a first week dose of 20 mg/day, the paroxetine regimen was increased to 40 mg/day for 5 weeks. Patients and their female partners were interviewed separately. Patients treated with paroxetine had significantly greater clinical improvement than the patients given placebo.
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            Premature ejaculation and serotonergic antidepressants-induced delayed ejaculation: the involvement of the serotonergic system.

            Premature ejaculation has generally been considered a psychosexual disorder with psychogenic aetiology. Although still mainly treated by behavioural therapy, in recent years double-blind studies have indicated the beneficial effects of some of the serotonergic antidepressants (SSRIs) in delaying ejaculation. We describe here the neurophysiology and the peripheral neuroanatomy of ejaculation and provide a review of the involvement of serotonin in the central nervous system in relation to serotonergic nuclei and their projections. A hypothesis of the role of 5-HT1A and 5-HT2C receptors in premature ejaculation is postulated.
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              Sexual dysfunctions in depression.

              The incidence of sexual dysfunctions in a group of 51 drug-free depressed patients and in age- and sex-matched controls was studied. Three groups of sexual dysfunction were assessed: alterations of libido, genital symptoms, and menstrual irregularities. The Beck Rating Scale for Depression, the Eysenck Personality Inventory (EPI), and the State-Trait Anxiety Inventory were completed on each participant. Depressed patients obtained significantly higher scores on anxiety, depression, and alterations of libido than controls. Rating scale scores for anxiety and depression were strongly intercorrelated, making the separation of depression-related symptoms from anxiety difficult. In males, the genital symptoms correlated inversely with the L (lie) score of the Eysenck Personality Inventory. There were no interrelationships between the three groups of sexual dysfunction.
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                Author and article information

                Journal
                Journal of Clinical Psychopharmacology
                Journal of Clinical Psychopharmacology
                Ovid Technologies (Wolters Kluwer Health)
                0271-0749
                1998
                August 1998
                : 18
                : 4
                : 274-281
                Article
                10.1097/00004714-199808000-00004
                7f2c409b-faee-4425-a9d3-bfa446c406d0
                © 1998
                History

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