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      Supraphysiological Doses of Growth Hormone: Effects on Muscles and Collagen in Healthy Active Young Adults

      Hormone Research in Paediatrics

      S. Karger AG

      Muscle, Young adult, Collagen, Doping, Growth hormone

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          Abstract

          Doping with growth hormone (GH) is a problem among both elite athletes and ordinary young adults who use gyms. However, the role of GH as an effective anabolic muscle doping agent, when taken alone, is questioned, although at lower doses GH may be seen to be effective when taken together with other anabolic androgenic steroids. Furthermore, GH doping does not seem to have any positive effects on cardiac performance, and fluid retention and other acromegalic side-effects reduce its use. A positive effect of supraphysiological doses of GH does seem to be the stimulation of collagen synthesis, though, which could lower the risk of muscle and tendon rupture, allow ruptured muscles and tendons to heal faster, and allow harder training with shorter recovery periods. This may explain its ongoing use as a doping agent. Moreover, it cannot be excluded that in the future this effect on collagen synthesis could become useful in clinical practice for the treatment of muscle and tendon ruptures.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          978-3-8055-8244-5
          978-3-318-01440-2
          1663-2818
          1663-2826
          2006
          January 2007
          25 January 2007
          : 66
          : Suppl 1
          : 98-104
          Affiliations
          Endocrine Section, Sahlgrenska University Hospital, Göteborg, Sweden
          Article
          96631 Horm Res 2006;66:98–104
          10.1159/000096631
          © 2006 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Figures: 3, References: 25, Pages: 7
          Categories
          Effects of GH in Adults

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